The highly diverse antiphage defence systems of bacteria
H Georjon, A Bernheim - Nature Reviews Microbiology, 2023 - nature.com
Bacteria and their viruses have coevolved for billions of years. This ancient and still ongoing
arms race has led bacteria to develop a vast antiphage arsenal. The development of high …
arms race has led bacteria to develop a vast antiphage arsenal. The development of high …
[HTML][HTML] Progress in gene editing tools, implications and success in plants: a review
Genetic modifications are made through diverse mutagenesis techniques for crop
improvement programs. Among these mutagenesis tools, the traditional methods involve …
improvement programs. Among these mutagenesis tools, the traditional methods involve …
[HTML][HTML] Antiviral type III CRISPR signalling via conjugation of ATP and SAM
CRISPR systems are widespread in the prokaryotic world, providing adaptive immunity
against mobile genetic elements,. Type III CRISPR systems, with the signature gene cas10 …
against mobile genetic elements,. Type III CRISPR systems, with the signature gene cas10 …
Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling
Prokaryotic type III CRISPR-Cas antiviral systems employ cyclic oligoadenylate (cAn)
signaling to activate a diverse range of auxiliary proteins that reinforce the CRISPR-Cas …
signaling to activate a diverse range of auxiliary proteins that reinforce the CRISPR-Cas …
Type III-B CRISPR-Cas cascade of proteolytic cleavages
The generation of cyclic oligoadenylates and subsequent allosteric activation of proteins that
carry sensory domains is a distinctive feature of type III CRISPR-Cas systems. In this work …
carry sensory domains is a distinctive feature of type III CRISPR-Cas systems. In this work …
DNA-targeting short Argonautes complex with effector proteins for collateral nuclease activity and bacterial population immunity
M Prostova, A Kanevskaya, V Panteleev… - Nature …, 2024 - nature.com
Two prokaryotic defence systems, prokaryotic Argonautes (pAgos) and CRISPR–Cas, detect
and cleave invader nucleic acids using complementary guides and the nuclease activities of …
and cleave invader nucleic acids using complementary guides and the nuclease activities of …
Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2
K Jungfer, A Sigg, M Jinek - Nucleic Acids Research, 2024 - academic.oup.com
Abstract Type III CRISPR-Cas systems provide adaptive immunity against foreign mobile
genetic elements through RNA-guided interference. Sequence-specific recognition of RNA …
genetic elements through RNA-guided interference. Sequence-specific recognition of RNA …
Coordinated proteome change precedes cell lysis and death in a mat-forming cyanobacterium
J Zorz, AJ Paquette, T Gillis, A Kouris, V Khot… - The ISME …, 2023 - academic.oup.com
Cyanobacteria form dense multicellular communities that experience transient conditions in
terms of access to light and oxygen. These systems are productive but also undergo …
terms of access to light and oxygen. These systems are productive but also undergo …
Function of the RNA-targeting class 2 type VI CRISPR Cas system of Rhodobacter capsulatus
Bacteria use CRISPR Cas systems to defend against invading foreign nucleic acids, eg,
phage genomes, plasmids or mobile genetic elements. Some CRISPR Cas systems were …
phage genomes, plasmids or mobile genetic elements. Some CRISPR Cas systems were …
[HTML][HTML] Interference Requirements of Type III CRISPR-Cas Systems from Thermus thermophilus
Among the diverse prokaryotic adaptive immunity mechanisms, the Type III CRISPR-Cas
systems are the most complex. The multisubunit Type III effectors recognize RNA targets …
systems are the most complex. The multisubunit Type III effectors recognize RNA targets …