Synthetic biology is a rapidly expanding discipline at the interface between engineering and
biology. Much research in this area has focused on gene regulatory networks that function …

The circadian timing system comprises a network of time‐keeping clocks distributed across
a living host whose responsibility is to allocate resources and distribute functions temporally …

Animals increase by orders of magnitude in volume during development. Therefore, small
variations in growth rates among individuals could amplify to a large heterogeneity in size …

Gene expression oscillators can structure biological events temporally and spatially.
Different biological functions benefit from distinct oscillator properties. Thus, finite …

The biologist JBS Haldane, when asked what we can learn about the Creator by examining
the world, is said to have replied “an inordinate fondness for beetles”[705]. Today's …

To introduce this special issue on biological switches and clocks, we review the historical
development of mathematical models of bistability and oscillations in chemical reaction …

The pattern of gene expression in a developing tissue determines the spatial organization of
cell type generation. We previously defined regulatory interactions between a set of …

Multisite phosphorylation plays an important role in biological oscillators such as the
circadian clock. Its general role, however, has been elusive. In this theoretical study, we …

Gene regulatory circuits are to the cell what arithmetic logic units are to the chip:
fundamental components of information processing that map an input onto an output. Gene …

Design and implementation of robust network modules is essential for construction of
complex biological systems through hierarchical assembly of 'parts' and 'devices'. The …