Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies;
however, patients can experience cardiotoxic effects and this has limited the use of this …

Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been
associated with leukopenia and uncontrolled inflammatory response in critically ill patients …

Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

Abstract Coronavirus disease 2019 (COVID-19), caused by the virus designated as severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread widely throughout the …

Inflammasomes are important sentinels of innate immune defence, sensing pathogens and
inducing cell death in infected cells. There are several inflammasome sensors that each …

Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic
drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit …

Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Cell death provides host defense and maintains homeostasis. Zα-containing molecules are
essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell …

Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …