Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery

T Burnouf, ML Chou, DJ Lundy, EY Chuang… - Journal of Biomedical …, 2023 - Springer
Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …

Blood derived eye drops for the treatment of cornea and ocular surface diseases

G Giannaccare, P Versura, M Buzzi, L Primavera… - … and Apheresis Science, 2017 - Elsevier
The use of blood derived eye drops for the treatment of ocular surface disorders has become
increasingly popular in recent years. The mechanism of action is the stimulation of cellular …

The molecular basis of neurotrophic keratopathy: Diagnostic and therapeutic implications. A review

RE Ruiz-Lozano, JC Hernandez-Camarena… - The ocular …, 2021 - Elsevier
Neurotrophic keratopathy (NK) is a degenerative corneal disease produced by different
factors, including infection, trauma, and neurogenesis, that lead to trigeminal nerve damage …

Reflections on dry eye syndrome treatment: therapeutic role of blood products

VJ Drew, CL Tseng, J Seghatchian, T Burnouf - Frontiers in medicine, 2018 - frontiersin.org
Dry eye syndrome (DES) is a multifactorial, frequent, pathology characterized by deficient
tear production or increased evaporation of tears and associated with ocular surface …

Blood-based treatments for severe dry eye disease: the need of a consensus

F Bernabei, M Roda, M Buzzi, M Pellegrini… - Journal of Clinical …, 2019 - mdpi.com
The use of blood-based eye drops as therapy for various diseases of the ocular surface has
become increasingly popular in ophthalmic practice during recent years. The rationale for …

[HTML][HTML] Autologous serum and serum components

A Higuchi - Investigative ophthalmology & visual science, 2018 - tvst.arvojournals.org
Dry eye syndrome is a multifactorial condition on the tear and ocular surface. Autologous
serum eye drop is an effective method for treating dry eye. Autologous serum eye drops are …

Autologous serum eye drops for ocular surface disorders

D Cui, G Li, EK Akpek - Current opinion in allergy and clinical …, 2021 - journals.lww.com
Autologous serum eye drops for ocular surface disorders : Current Opinion in Allergy and
Clinical Immunology Autologous serum eye drops for ocular surface disorders : Current Opinion …

[HTML][HTML] New developments in the management of persistent corneal epithelial defects

ZZ Thia, YT Ho, KC Shih, L Tong - Survey of ophthalmology, 2023 - Elsevier
A persistent epithelial defect (PED) is a corneal epithelial defect that failed to heal after 2
weeks. It is a condition that carries much morbidity, and our understanding of PED remains …

Regenerative therapies in dry eye disease: from growth factors to cell therapy

AJ Villatoro, V Fernández, S Claros… - International Journal of …, 2017 - mdpi.com
Dry eye syndrome is a complex and insidious pathology with a high level of prevalence
among the human population and with a consequently high impact on quality of life and …

Eye drops of human origin—Current status and future needs: Report on the workshop organized by the ISBT Working Party for Cellular Therapies

C Gabriel, DC Marks, R Henschler… - Vox …, 2023 - Wiley Online Library
Abstract Background and Objectives Serum eye drops (SEDs) are used to treat ocular
surface disease (OSD) and to promote ocular surface renewal. However, their use and …