[HTML][HTML] Parkinson's disease: alterations in iron and redox biology as a key to unlock therapeutic strategies
A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …
(PD). The literature reveals well-documented alterations consistent with established dogma …
Molecular evolution of the transferrin family and associated receptors
LA Lambert - Biochimica et Biophysica Acta (BBA)-General Subjects, 2012 - Elsevier
BACKGROUND: In vertebrates, serum transferrins are essential iron transporters that have
bind and release Fe (III) in response to receptor binding and changes in pH. Some family …
bind and release Fe (III) in response to receptor binding and changes in pH. Some family …
The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action
GYL Lui, P Obeidy, SJ Ford, C Tselepis, DM Sharp… - Molecular …, 2013 - ASPET
Deferasirox is an orally effective iron (Fe) chelator currently used for the treatment of iron-
overload disease and has been implemented as an alternative to the gold standard chelator …
overload disease and has been implemented as an alternative to the gold standard chelator …
Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti‐tumour efficacy
Y Yu, YS Rahmanto… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE Our previous studies demonstrated that a
thiosemicarbazone iron chelator (di‐2‐pyridylketone‐4, 4‐dimethyl‐3‐thiosemicarbazone; …
thiosemicarbazone iron chelator (di‐2‐pyridylketone‐4, 4‐dimethyl‐3‐thiosemicarbazone; …
Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in Drosophila
K Tiklová, KA Senti, S Wang, A Gräslund… - Nature cell …, 2010 - nature.com
Iron is an essential element in many biological processes. In vertebrates, serum transferrin is
the major supplier of iron to tissues, but the function of additional transferrin-like proteins …
the major supplier of iron to tissues, but the function of additional transferrin-like proteins …
Melanotransferrin: search for a function
YS Rahmanto, S Bal, KH Loh, Y Yu… - Biochimica et Biophysica …, 2012 - Elsevier
BACKGROUND: Melanotransferrin was discovered in the 1980s as one of the first
melanoma tumour antigens. The molecule is a transferrin homologue that is found …
melanoma tumour antigens. The molecule is a transferrin homologue that is found …
[HTML][HTML] The membrane-bound and soluble form of melanotransferrin function independently in the diagnosis and targeted therapy of lung cancer
Y Lei, Z Lu, J Huang, R Zang, Y Che, S Mao… - Cell Death & …, 2020 - nature.com
Melanotransferrin (MFI2) is a newly identified tumor-associated protein, which consists of
two forms of proteins, membrane-bound (mMFI2) and secretory (sMFI2). However, little is …
two forms of proteins, membrane-bound (mMFI2) and secretory (sMFI2). However, little is …
Melanotransferrin: New Homolog Genes and Their Differential Expression during Intestinal Regeneration in the Sea Cucumber Holothuria glaberrima
J Hernández‐Pasos, G Valentín‐Tirado… - … Zoology Part B …, 2017 - Wiley Online Library
Melanotransferrin (MTf) is a protein associated with oncogenetic, developmental, and
immune processes which function remains unclear. The MTf gene has been reported in …
immune processes which function remains unclear. The MTf gene has been reported in …
Melanotransferrin Functions as a Pro-Oncogenic WNT Agonist: A Yin-Yang Relationship in Melanoma with the WNT Antagonist and Metastasis Suppressor, NDRG1
J Paluncic, M Gholam Azad, DJR Lane, J Skoda… - bioRxiv, 2023 - biorxiv.org
A persistent mystery in the melanoma field has been the function of one of the first
melanoma tumor antigens characterized, namely p97 (melanotransferrin; MTf). While MTf …
melanoma tumor antigens characterized, namely p97 (melanotransferrin; MTf). While MTf …
[HTML][HTML] Complex of human Melanotransferrin and SC57. 32 Fab fragment reveals novel interdomain arrangement with ferric N-lobe and open C-lobe
K Hayashi, KL Longenecker, YL Liu, B Faust… - Scientific Reports, 2021 - nature.com
Melanotransferrin (MTf) is an iron-binding member of the transferrin superfamily that can be
membrane-anchored or secreted in serum. On cells, it can mediate transferrin-independent …
membrane-anchored or secreted in serum. On cells, it can mediate transferrin-independent …