Sensitivity of salivary glands to radiation: from animal models to therapies

O Grundmann, GC Mitchell… - Journal of dental …, 2009 - journals.sagepub.com
Radiation therapy for head and neck cancer causes significant secondary side-effects in
normal salivary glands, resulting in diminished quality of life for these individuals. Salivary …

Evidence-based radiation oncology in head and neck squamous cell carcinoma

R Corvò - Radiotherapy and Oncology, 2007 - Elsevier
BACKGROUND AND PURPOSE: Historically, radiation therapy (RT) has been an available
treatment option for patients with early resectable head and neck squamous cell carcinoma …

Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma

KL Bennett, M Karpenko, M Lin, R Claus, K Arab… - Cancer research, 2008 - AACR
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive cancer. In
advanced stages, the patient has poor chances of receiving effective treatment, and survival …

[HTML][HTML] P21Cip1/WAF1 expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis

HC Hafkamp, JJ Mooren, SMH Claessen… - Modern Pathology, 2009 - Elsevier
Human papillomavirus is involved in the carcinogenesis of tonsillar squamous cell
carcinomas. Here, we investigated the expression and the prognostic value of key cell cycle …

Tumor suppressor activity of CCAAT/enhancer binding protein α is epigenetically down-regulated in head and neck squamous cell carcinoma

KL Bennett, B Hackanson, LT Smith, CD Morrison… - Cancer research, 2007 - AACR
Tumor suppressor CCAAT enhancer binding protein α (C/EBPα) is a transcription factor
involved in cell cycle control and cellular differentiation. In a recent study, microarray …

[HTML][HTML] Prognostic value of immune checkpoint molecules in head and neck cancer: a meta-analysis

YQ Jia, B Yang, LL Wen, WX Mu, Z Wang… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Immune checkpoint molecules are important targets in cancer immunotherapy, but their
association with prognosis in patients with head and neck cancer is controversial. In this …

Immune alterations and immunotherapy prospects in head and neck cancer

V Varilla, J Atienza, CA Dasanu - Expert opinion on biological …, 2013 - Taylor & Francis
Introduction: Several literature sources have suggested that subjects with head and neck
squamous cell carcinoma (HNSCC) display significant abnormalities of immunocompetent …

Molecular mechanisms of head and neck cancer

AM Deshpande, DT Wong - Expert review of anticancer therapy, 2008 - Taylor & Francis
Despite advances in understanding the underlying genetics, squamous cell carcinoma of
the head and neck (SCCHN) remains a major health risk and one of the leading causes of …

[HTML][HTML] Targeting Toll-like receptor 2 inhibits growth of head and neck squamous cell carcinoma

L Farnebo, A Shahangian, Y Lee, JH Shin… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Infection-driven inflammation has been proposed to be involved in the tumorigenesis of
head and neck squamous cell carcinoma (HNSCC). Oral HNSCC is often colonized with …

MicroRNA-145-5p aggravates cell apoptosis and oxidative stress in tongue squamous cell carcinoma

Z Xin, Z Tong, J Tan, C Liu - Experimental and …, 2021 - spandidos-publications.com
Abstract MicroRNA-145-5p (miR-145-5p) is expressed in a variety of tumors, but the
mechanism underlying miR-145-5p in tongue squamous cell carcinoma (TSCC) is not fully …