Background: Age-related rotator cuff tendinopathy (RCT) is associated with increased rotator
cuff tear and postoperative retear rates. This study aimed to determine whether nicotinamide …

Sigmar1 is a ubiquitously expressed, multifunctional protein known for its cardioprotective
roles in cardiovascular diseases. While accumulating evidence indicate a critical role of …

Ethnopharmacological relevance Hyperlipidemia as a major health issue has attracted
much public attention. As a geographical indication product of China, Liupao tea (LPT) is a …

A variety of complex risk factors and pathological mechanisms contribute to myocardial
stress, which ultimately promotes the development of cardiovascular diseases, including …

Accumulating evidence highlights the key importance of innate immunity in heart
hypertrophy and failure. Though stimulator of interferon genes (STING) is an integral innate …

Skeletal muscle plays a vital role in the regulation of systemic metabolism, partly through its
secretion of endocrine factors which are collectively known as myokines. Altered myokine …

Background: Aging patients easily suffer from non-ST segment elevation myocardial
infarction (NSTEMI). Our previous studies revealed declined function of endothelial …

Background Defects of mitophagy, the selective form of autophagy for mitochondria, are
commonly observed in several cardiovascular diseases and represent the main cause of …

Background Age-related visceral obesity could contribute to the development of
cardiometabolic complications. The pathogenesis of visceral fat mass accumulation during …

Objective: Cardiovascular disease (CVD) is a global health crisis and a leading cause of
mortality. The intricate interplay between vascular contractility and mitochondrial function is …