A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …

Human T cell leukemia virus type 1 (HTLV-1), also known as human T lymphotropic virus
type 1, was the first exogenous human retrovirus discovered. Unlike the distantly related …

The progressive loss of immunological memory during aging correlates with a reduced
proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that …

Human T-cell leukemia virus-1 (HTLV-1) is a neglected and incurable retrovirus estimated to
infect 5 to 10 million worldwide. Specific indigenous Australian populations report infection …

HTLV-1 uveitis (HU) is the third clinical entity to be designated as an HTLV-1-associated
disease. Although HU is considered to be the second-most frequent HTLV-1-associated …

Abstract Background The Human T-cell Lymphotropic Virus Type-1 (HTLV-1) is a blood-
borne pathogen and etiological agent of Adult T-cell Leukemia/Lymphoma (ATLL) and HTLV …

Simple Summary The expression of the telomerase reverse transcriptase (TERT) gene is
commonly repressed in terminally differentiated somatic cells and becomes reactivated in …

In 1964, Epstein, Barr, and Achong published a report outlining their discovery of viral
particles in lymphoblasts isolated from a patient with Burkitt lymphoma. The Epstein-Barr …

When the JCI began publishing in 1924, the world was recovering from the end of the First
World War and the lingering aftermath of the 1918 influenza pandemic. The 100th …