In spite of the huge progress in the treatment of diabetes mellitus, we are still in the situation
that both pregestational (PGDM) and gestational diabetes (GDM) impose an additional risk …

Recent evidence indicates that perinatal exposure to maternal obesity, metabolic disease,
including diabetes and hypertension, and unhealthy maternal diet has a long-term impact on …

Maternal obesity is associated with increased risks of pregnancy complications. Excessive
fat mass, common to obese women, has the potential to influence production and secretion …

Leptin is an adipokine that acts in the central nervous system and regulates energy balance.
Animal models and human observational studies have suggested that leptin surge in the …

Consumption of a high-fat diet has long been known to increase risk for obesity, diabetes,
and the metabolic syndrome. Further evidence strongly suggests that these same metabolic …

Maternal nutrition may influence metabolic profiles in offspring. We aimed to investigate the
effect of maternal folic acid supplement on glucose metabolism in mouse offspring fed a high …

Mankind exposure to chemicals in the past century has increased dramatically throughout
environment. There is no question that chemicals interfere with the physiology of biological …

The maternal environment during pregnancy is critical for fetal development and perinatal
perturbations can prime offspring disease risk. Here, we briefly review evidence linking two …

Pregnancy involves a range of metabolic adaptations to supply adequate energy for fetal
growth and development. Gestational diabetes (GDM) is defined as hyperglycemia with first …

Background Obesity and type-2 diabetes are on the rise and in utero exposure to
environmental contaminants is a suspected contributing factor. Our objective was to …