The genetics of complex cholestatic disorders
GM Hirschfield, RW Chapman, TH Karlsen, F Lammert… - Gastroenterology, 2013 - Elsevier
Cholestatic liver diseases are caused by a range of hepatobiliary insults and involve
complex interactions among environmental and genetic factors. Little is known about the …
complex interactions among environmental and genetic factors. Little is known about the …
Genetics of gallstone disease
C Rebholz, M Krawczyk… - European journal of clinical …, 2018 - Wiley Online Library
Background Gallstone disease (GD) belongs to the most frequent disorders in
gastroenterology and causes high costs in our health‐care systems. Gallstones are …
gastroenterology and causes high costs in our health‐care systems. Gallstones are …
[HTML][HTML] Blood lipid metabolism and the risk of gallstone disease: a multi-center study and meta-analysis
M Zhang, M Mao, C Zhang, F Hu, P Cui, G Li… - Lipids in Health and …, 2022 - Springer
Background Gallstone disease (GSD) is a common and costly biliary disorder. Multiple
studies have investigated the associations between blood lipid metabolism and GSD risk; …
studies have investigated the associations between blood lipid metabolism and GSD risk; …
[HTML][HTML] Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease …
S Calandra, P Tarugi, HE Speedy, AF Dean… - Journal of lipid …, 2011 - ASBMB
This review integrates historical biochemical and modern genetic findings that underpin our
understanding of the low-density lipoprotein (LDL) dyslipidemias that bear on human …
understanding of the low-density lipoprotein (LDL) dyslipidemias that bear on human …
[PDF][PDF] Gallstone disease and type 2 diabetes risk: a Mendelian randomization study
F Wang, J Wang, Y Li, J Yuan, P Yao, S Wei… - …, 2019 - Wiley Online Library
The presence of gallstone disease (GSD) was reported to be positively associated with
diabetes risk. Whether the association is causal remains unclear. We aim to examine the …
diabetes risk. Whether the association is causal remains unclear. We aim to examine the …
Dissecting the genetic heterogeneity of gallbladder stone formation
M Krawczyk, DQH Wang, P Portincasa… - Seminars in liver …, 2011 - thieme-connect.com
Gallstone disease affects almost 20% of individuals in Westernized countries. As its
incidence in the developing countries is rising considerably, currently, it is the second most …
incidence in the developing countries is rising considerably, currently, it is the second most …
Genetics of gallstone disease
SC Chuang, E Hsi, KT Lee - Advances in clinical chemistry, 2013 - Elsevier
Gallstone disease (GSD) is one of the most common biliary tract disorders worldwide. The
prevalence, however, varies from 5.9–21.9% in Western society to 3.1–10.7% in Asia. Most …
prevalence, however, varies from 5.9–21.9% in Western society to 3.1–10.7% in Asia. Most …
[HTML][HTML] Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease
O Renner, D Lütjohann, D Richter, A Strohmeyer… - BMC …, 2013 - Springer
Background Gallstone disease is associated with p. D19H of ABCG8 as well as alterations
of cholesterol and bile acid metabolism. However, molecular mechanisms have not been …
of cholesterol and bile acid metabolism. However, molecular mechanisms have not been …
[HTML][HTML] Risk of gallstones based on ABCG8 rs11887534 single nucleotide polymorphism among Taiwanese men and women
Background Gallstones are abnormal masses caused by impaired metabolism of
cholesterol, bilirubin, or bile salts in the gallbladder or biliary tract. ATP-binding cassette …
cholesterol, bilirubin, or bile salts in the gallbladder or biliary tract. ATP-binding cassette …
Variation and evolution of the ABC transporter genes ABCB1, ABCC1, ABCG2, ABCG5 and ABCG8: implication for pharmacogenetics and disease
The ATP-binding cassette (ABC) transporter genes are ubiquitous in the genomes of all
vertebrates. Some of these transporters play a key role in xenobiotic defense and are …
vertebrates. Some of these transporters play a key role in xenobiotic defense and are …