The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

Single-cell technologies have enabled the characterization of the tumour microenvironment
at unprecedented depth and have revealed vast cellular diversity among tumour cells and …

Glioblastoma (GBM) is the most aggressive form of primary brain tumor, for which effective
therapies are urgently needed. Cancer cells are capable of evading clearance by …

Myeloid cells are a significant proportion of leukocytes within tissues, comprising
granulocytes, monocytes, dendritic cells, and macrophages. With the identification of various …

Aims Macrophages have a critical and dual role in post-ischaemic cardiac repair, as they
can foster both tissue healing and damage. Multiple subsets of tissue resident and monocyte …

CNS-resident macrophages—including parenchymal microglia and border-associated
macrophages (BAMs)—contribute to neuronal development and health, vascularization, and …

Maintaining macrophage (MΦ) heterogeneity is critical to ensure intestinal tissue
homeostasis and host defense. The gut microbiota and host factors are thought to …

Cerebral ischemia triggers a powerful inflammatory reaction involving peripheral leukocytes
and brain resident cells that contribute to both tissue injury and repair. However, their …

The recent revolution in tissue-resident macrophage biology has resulted largely from
murine studies performed in C57BL/6 mice. Here, using both C57BL/6 and BALB/c mice, we …