The purpose of this review was to evaluate data generated by animal models of
intervertebral disc (IVD) degeneration published in the last decade and show how this has …

Animal models have been invaluable in the identification of molecular events occurring in
and contributing to intervertebral disc (IVD) degeneration and important therapeutic targets …

Atherosclerosis (AS) is a chronic inflammatory disease characterized by hardening and
narrowing of arteries. AS leads to a number of arteriosclerotic vascular diseases including …

The natural compound plumbagin has a wide range of pharmacological and potential
therapeutic activities, although its role in neuroretina degeneration is unknown. Here we …

Cardiovascular aging presents a formidable challenge, as the aging process can lead to
reduced cardiac function and heightened susceptibility to cardiovascular diseases …

Diabetes mellitus, a group of metabolic disorders characterized by high levels of blood
glucose caused by insulin defect or impairment, is a major risk factor for cardiovascular …

Significance: Diabetes and its related complications are becoming an increasing public
health problem that affects hundreds of millions of people globally. Increased disability and …

Antioxidants have an important role in protecting against diabetes complications such as
vascular endothelial cell damage. Fucoidan has strong antioxidant properties, therefore the …

An autoimmune disease is the consequence of the immune system attacking healthy cells,
tissues, and organs by mistake instead of protecting them. Inflammation and oxidative stress …

Cardiovascular diseases represent a significant worldwide problem, jeopardizing
individuals' physical and mental wellbeing as well as their quality of life as a result of their …