Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

Aging promotes lung function decline and susceptibility to chronic lung diseases, which are
the third leading cause of death worldwide. Here, we use single cell transcriptomics and …

Pneumonia is a type of acute lower respiratory infection that is common and severe. The
outcome of lower respiratory infection is determined by the degrees to which immunity is …

Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the
pathogenesis of various chronic diseases and aging-related organ failure to fully control …

The development and clinical implementation of direct-acting antivirals (DAAs) has
revolutionized the treatment of chronic hepatitis C. Infection with any hepatitis C virus (HCV) …

The rapid expansion of the elderly population has led to the recent epidemic of age-related
diseases, including increased incidence and mortality of chronic and acute lung diseases …

Prevalence of asthma in older adults is growing along with increasing global life expectancy.
Due to poor clinical consequences such as high mortality, advancement in understanding …

Collagen is the most abundant airway extracellular matrix component and is the primary
determinant of mechanical airway properties. Abnormal airway collagen deposition is …

Lung function declines with advancing age. To improve our understanding of the structure-
function relationships leading to this decline, we investigated structural alterations in the …