[HTML][HTML] Human organoids in basic research and clinical applications
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
[HTML][HTML] Human organoids: model systems for human biology and medicine
The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …
made it challenging to address questions that are specific to the understanding of human …
[HTML][HTML] Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro
model to recapitulate human brain development and neurological diseases. However, the …
model to recapitulate human brain development and neurological diseases. However, the …
Generation of vascularized brain organoids to study neurovascular interactions
XY Sun, XC Ju, Y Li, PM Zeng, J Wu, YY Zhou… - elife, 2022 - elifesciences.org
Brain organoids have been used to recapitulate the processes of brain development and
related diseases. However, the lack of vasculatures, which regulate neurogenesis and brain …
related diseases. However, the lack of vasculatures, which regulate neurogenesis and brain …
[HTML][HTML] Human organoid models to study SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
[HTML][HTML] An in vivo neuroimmune organoid model to study human microglia phenotypes
Microglia are specialized brain-resident macrophages that play crucial roles in brain
development, homeostasis, and disease. However, until now, the ability to model …
development, homeostasis, and disease. However, until now, the ability to model …
Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo
I Chiaradia, MA Lancaster - Nature Neuroscience, 2020 - nature.com
Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …
[HTML][HTML] Challenges of organoid research
MG Andrews, AR Kriegstein - Annual review of neuroscience, 2022 - annualreviews.org
Organoids are 3D cell culture systems derived from human pluripotent stem cells that
contain tissue resident cell types and reflect features of early tissue organization. Neural …
contain tissue resident cell types and reflect features of early tissue organization. Neural …
[HTML][HTML] Sliced human cortical organoids for modeling distinct cortical layer formation
Human brain organoids provide unique platforms for modeling development and diseases
by recapitulating the architecture of the embryonic brain. However, current organoid …
by recapitulating the architecture of the embryonic brain. However, current organoid …
[HTML][HTML] Complex oscillatory waves emerging from cortical organoids model early human brain network development
Structural and transcriptional changes during early brain maturation follow fixed
developmental programs defined by genetics. However, whether this is true for functional …
developmental programs defined by genetics. However, whether this is true for functional …