Tumor necrosis factor-alpha (TNF-α) is a pleiotropic immune cytokine that belongs to the
TNF superfamily of receptor ligands. The cytokine exists as either a transmembrane or a …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

The TNF-α/TNFR system is involved in endometriosis (EDT), a gynecologic estrogen-
dependent disease. Elevated copper concentrations have also been associated with EDT …

Apoptosis is a programmed cell death process critical to cell development and tissue
homeostasis in multicellular organisms. Defective apoptosis is a crucial step in the …

The tumor microenvironment of colorectal cancer (CRC) is heterogenous; thus, it is likely
that multiple immune-related and inflammatory markers are simultaneously expressed in the …

Simple Summary High-grade serous ovarian cancer (HGSOC) remains a lethal malignancy.
There is an urgent need to establish whether a mass is benign or malignant prior to surgery …

Nanodynamic therapy (NDT) exerts its anti-tumor effect by activating nanosensitizers to
generate large amounts of reactive oxygen species (ROS) in tumor cells. NDT enhances …

Cellular responses to TNF are inherently heterogeneous within an isogenic cell population
and across different cell types. TNF promotes cell survival by activating pro-inflammatory NF …

Background Protein kinase CK2 activity is implicated in the pathogenesis of various
hematological malignancies like Acute Myeloid Leukemia (AML) that remains challenging …

Clear-cell renal cell carcinoma (ccRCC), a tubular epithelial malignancy, secretes tumor
necrosis factor (TNF), which signals ccRCC cells in an autocrine manner via two cell surface …