An emerging body of literature demonstrates differences in the gut microbiome (GMB) of
patients with major depressive disorder (MDD) compared to healthy controls (HC), as well …

Background Varying conceptualizations of treatment‐resistant depression (TRD) have made
translating research findings or systematic reviews into clinical practice guidelines …

Background Growing attention has been paid to the field of gut microbiota for mental
disorders over the last decade. However, to our knowledge, no studies have conducted …

Objective To compare the efficacy and discontinuation of augmentation agents in adult
patients with treatment-resistant depression (TRD). We conducted a systematic review and …

Background The benefits and risks of augmenting or switching antidepressants in older
adults with treatment-resistant depression have not been extensively studied. Methods We …

Background Many depressed patients are not able to achieve or sustain symptom remission
despite serial treatment trials–often termed “treatment resistant depression”. A broader …

Although deep brain stimulation (DBS) is an established treatment choice for Parkinson's
disease (PD), essential tremor and movement disorders, its effectiveness for the …

Abnormalities of the kynurenine (KYN) pathway may be implicated in the pathophysiology of
depression. However, the relationships between depression and each metabolite of the …

BackgroundMeta-analyses have shown that high-frequency (HF) repetitive transcranial
magnetic stimulation (rTMS) has antidepressant properties when compared with sham …

It is of considerable translational importance whether depression is a form or a consequence
of sickness behavior. Sickness behavior is a behavioral complex induced by infections and …