Orthodontic tooth movement is based on the remodeling of tooth-surrounding tissues in
response to mechanical stimuli. During this process, human periodontal ligament cells …

Osteoporosis is a systemic skeletal disorder characterized by a decrease in bone mass and
microarchitectural deterioration of bone tissue. The World Health Organization has defined …

Bivalent epigenomic regulatory domains containing both activating histone 3 lysine 4
(H3K4me3) and repressive lysine 27 (H3K27me3) trimethylation are associated with key …

RNA modification is a type of post‑transcriptional modification that regulates important
cellular pathways, such as the processing and metabolism of RNA. The most abundant form …

Osteoporosis is characterized by decreased bone mass and adipocyte accumulation within
the bone marrow that inhibits osteoblast maturation, leading to a high risk of fractures. Thus …

Heterotopic ossification (HO) manifests as bone development in the skeletal muscles and
surrounding soft tissues. It can be caused by injury, surgery, or may have a genetic …

Emerging evidence has indicated that dysregulated microRNAs (miRNAs) have an
important role in bone formation. However, the pathophysiological role of miRNAs in …

Wharton's Jelly mesenchymal stem cells (WJ‐MSCs) are an attractive potential source of
multipotent stem cells for bone tissue replacement therapies. However, the molecular …

Studies from both humans and animal models indicated that maternal chronic poor-quality
diet, especially a high fat diet (HFD), is significantly associated with reduced bone density …

Objectives Bone marrow derived mesenchymal stem cells (BMSCs) are an irresistible
choice for use in stem cell therapy and regenerative medicine. BMSCs osteoblastic …