Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections

Y Zhu, W Hao, X Wang, J Ouyang… - Medicinal Research …, 2022 - Wiley Online Library
Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important
effector immune defense molecules in multicellular organisms. AMPs exert their …

New Treatment Options against Carbapenem-Resistant Acinetobacter baumannii Infections

B Isler, Y Doi, RA Bonomo… - Antimicrobial agents and …, 2019 - Am Soc Microbiol
Carbapenem-resistant Acinetobacter baumannii (CRAB) is a perilous nosocomial pathogen
causing substantial morbidity and mortality. Current treatment options for CRAB are limited …

International consensus guidelines for the optimal use of the polymyxins: endorsed by the American college of clinical pharmacy (ACCP), European society of clinical …

BT Tsuji, JM Pogue, AP Zavascki… - … : The Journal of …, 2019 - Wiley Online Library
The polymyxin antibiotics colistin (polymyxin E) and polymyxin B became available in the
1950s and thus did not undergo contemporary drug development procedures. Their clinical …

Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised …

M Paul, GL Daikos, E Durante-Mangoni… - The lancet Infectious …, 2018 - thelancet.com
Background Colistin–carbapenem combinations are synergistic in vitro against carbapenem-
resistant Gram-negative bacteria. We aimed to test whether combination therapy improves …

Effect of appropriate combination therapy on mortality of patients with bloodstream infections due to carbapenemase-producing Enterobacteriaceae (INCREMENT): a …

B Gutiérrez-Gutiérrez, E Salamanca… - The Lancet Infectious …, 2017 - thelancet.com
Background The best available treatment against carbapenemase-producing
Enterobacteriaceae (CPE) is unknown. The objective of this study was to investigate the …

Treatment of infections caused by multidrug-resistant gram-negative bacteria: Report of the British society for antimicrobial chemotherapy/healthcare infection society …

PM Hawkey, RE Warren, DM Livermore… - Journal of …, 2018 - academic.oup.com
Abstract The Working Party makes more than 100 tabulated recommendations in
antimicrobial prescribing for the treatment of infections caused by multidrug-resistant (MDR) …

Escherichia coli: an old friend with new tidings

J Vila, E Sáez-López, JR Johnson… - FEMS microbiology …, 2016 - academic.oup.com
Escherichia coli is one of the most-studied microorganisms worldwide but its characteristics
are continually changing. Extraintestinal E. coli infections, such as urinary tract infections …

Antibiotic strategies in the era of multidrug resistance

G Karam, J Chastre, MH Wilcox, JL Vincent - Critical Care, 2016 - Springer
The rapid emergence and dissemination of antibiotic-resistant microorganisms in ICUs
worldwide threaten adequate antibiotic coverage of infected patients in this environment …

Treatment Options for Carbapenem-Resistant Enterobacteriaceae Infections

HJ Morrill, JM Pogue, KS Kaye… - Open forum infectious …, 2015 - academic.oup.com
This article provides a comprehensive review of currently available treatment options for
infections due to carbapenem-resistant Enterobacteriaceae (CRE). Antimicrobial resistance …

[HTML][HTML] Management of carbapenem-resistant Enterobacteriaceae infections

E Durante-Mangoni, R Andini, R Zampino - Clinical Microbiology and …, 2019 - Elsevier
Background Carbapenem resistance is defined as in vitro non-susceptibility to any
carbapenem and/or documented production of a carbapenemase. This feature has rapidly …