A primary goal of human genetics is to identify DNA sequence variants that influence
biomedical traits, particularly those related to the onset and progression of human disease …

Starting with the launch of the Human Genome Project three decades ago, and continuing
after its completion in 2003, genomics has progressively come to have a central and …

Physical access to DNA is a highly dynamic property of chromatin that plays an essential
role in establishing and maintaining cellular identity. The organization of accessible …

Abstract Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) is widely
used in studying chromatin biology, but a comprehensive review of the analysis tools has …

Aging is associated with a progressive decline in cardiovascular structure and function.
Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a …

Organism viability relies on the stable maintenance of specific chromatin landscapes,
established during development, that shape cell functions and identities by driving distinct …

Chronic lymphocytic leukaemia (CLL) is characterized by substantial clinical heterogeneity,
despite relatively few genetic alterations. To provide a basis for studying epigenome …

Genome-wide association studies (GWASs) have identified thousands of loci associated
with hundreds of complex diseases and traits, and progress is being made toward …

Genome-wide association studies (GWAS) have transformed our understanding of
susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained …

Background Although spatial organization of compartments and topologically associating
domains at large scale is relatively well studied, the spatial organization of regulatory …