[HTML][HTML] Current strategies for exosome cargo loading and targeting delivery
Extracellular vesicles (EVs) such as ectosomes and exosomes have gained attention as
promising natural carriers for drug delivery. Exosomes, which range from 30 to 100 nm in …
promising natural carriers for drug delivery. Exosomes, which range from 30 to 100 nm in …
[HTML][HTML] New insight into circRNAs: characterization, strategies, and biomedical applications
XY Feng, SX Zhu, KJ Pu, HJ Huang, YQ Chen… - … Hematology & Oncology, 2023 - Springer
Circular RNAs (circRNAs) are a class of covalently closed, endogenous ncRNAs. Most
circRNAs are derived from exonic or intronic sequences by precursor RNA back-splicing …
circRNAs are derived from exonic or intronic sequences by precursor RNA back-splicing …
[HTML][HTML] A bioinformatics analysis, pre-clinical and clinical conception of autophagy in pancreatic cancer: complexity and simplicity in crosstalk
Pancreatic cancer (PC) is a serious gastrointestinal tract disease for which the 5-year
survival rate is less than 10%, even in developed countries such as the USA. The genomic …
survival rate is less than 10%, even in developed countries such as the USA. The genomic …
[HTML][HTML] CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis
Y Jiang, J Zhao, R Li, Y Liu, L Zhou, C Wang… - Journal of Experimental …, 2022 - Springer
Background Ferroptosis is a novel form of iron-dependent cell death and participates in the
malignant progression of glioblastoma (GBM). Although circular RNAs (circRNAs) are found …
malignant progression of glioblastoma (GBM). Although circular RNAs (circRNAs) are found …
[HTML][HTML] Recent advances of exosomal circRNAs in cancer and their potential clinical applications
Q Yi, J Yue, Y Liu, H Shi, W Sun, J Feng… - Journal of translational …, 2023 - Springer
Circular RNA (circRNA) is a type of non-coding RNA that forms a covalently closed,
uninterrupted loop. The expression of circRNA differs among cell types and tissues, and …
uninterrupted loop. The expression of circRNA differs among cell types and tissues, and …
[HTML][HTML] Upregulation of FAM83F by c-Myc promotes cervical cancer growth and aerobic glycolysis via Wnt/β-catenin signaling activation
C Zhang, L Liu, W Li, M Li, X Zhang, C Zhang… - Cell Death & …, 2023 - nature.com
Cervical cancer (CC) seriously affects women's health. Therefore, elucidation of the exact
mechanisms and identification of novel therapeutic targets are urgently needed. In this …
mechanisms and identification of novel therapeutic targets are urgently needed. In this …
[HTML][HTML] The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
S Guo, J Huang, G Li, W Chen, Z Li, J Lei - Molecular Cancer, 2023 - Springer
Current research has demonstrated that extracellular vesicles (EVs) and circulating tumor
cells (CTCs) are very closely related in the process of distant tumor metastasis. Primary …
cells (CTCs) are very closely related in the process of distant tumor metastasis. Primary …
Hypoxic regulation of extracellular vesicles: Implications for cancer therapy
S Yoo, S Choi, I Kim, IS Kim - Journal of Controlled Release, 2023 - Elsevier
Extracellular vesicles (EVs) play a pivotal role in intercellular communication and have been
implicated in cancer progression. Hypoxia, a pervasive hallmark of cancer, is known to …
implicated in cancer progression. Hypoxia, a pervasive hallmark of cancer, is known to …
[HTML][HTML] Emerging role of exosome-shuttled noncoding RNAs in gastrointestinal cancers: from intercellular crosstalk to clinical utility
B Xia, Y Liu, J Wang, Q Lu, X Lv, K Deng… - Pharmacological …, 2023 - Elsevier
Gastrointestinal cancer remains a significant global health burden. The pursuit of advancing
the comprehension of tumorigenesis, along with the identification of reliable biomarkers and …
the comprehension of tumorigenesis, along with the identification of reliable biomarkers and …
[HTML][HTML] A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and …
B Huang, J Ren, Q Ma, F Yang, X Pan, Y Zhang, Y Liu… - Molecular Cancer, 2024 - Springer
Background Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer
with high aggressive phenotype and poor prognosis. Accumulating evidence suggests that …
with high aggressive phenotype and poor prognosis. Accumulating evidence suggests that …