Evolving concepts of the vulnerable atherosclerotic plaque and the vulnerable patient: implications for patient care and future research

P Gaba, BJ Gersh, J Muller, J Narula… - Nature Reviews …, 2023 - nature.com
Understanding the natural history of coronary artery atherosclerosis is necessary to
determine prognosis and prescribe effective therapies. Traditional management of coronary …

Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior

YS Chatzizisis, AU Coskun, M Jonas… - Journal of the American …, 2007 - jacc.org
Although the entire coronary tree is exposed to the atherogenic effect of the systemic risk
factors, atherosclerotic lesions form at specific arterial regions, where low and oscillatory …

Extent, location, and clinical significance of non–infarct-related coronary artery disease among patients with ST-elevation myocardial infarction

DW Park, RM Clare, PJ Schulte, KS Pieper, LK Shaw… - Jama, 2014 - jamanetwork.com
Importance Little information exists about the anatomical characteristics and clinical
relevance of non–infarct-related artery (IRA) disease among patients with ST-segment …

The myth of the “vulnerable plaque” transitioning from a focus on individual lesions to atherosclerotic disease burden for coronary artery disease risk assessment

A Arbab-Zadeh, V Fuster - Journal of the American College of Cardiology, 2015 - jacc.org
The cardiovascular science community has pursued the quest to identify vulnerable
atherosclerotic plaque in patients for decades, hoping to prevent acute coronary events …

Noninvasive assessment of plaque morphology and composition in culprit and stable lesions in acute coronary syndrome and stable lesions in stable angina by …

U Hoffmann, F Moselewski, K Nieman, IK Jang… - Journal of the American …, 2006 - jacc.org
Objectives: The purpose of this study was to assess morphology and composition of culprit
and stable coronary lesions by multidetector computed tomography (MDCT). Background …

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

HB Sager, P Dutta, JE Dahlman, M Hulsmans… - Science translational …, 2016 - science.org
Myocardial infarction (MI) leads to a systemic surge of vascular inflammation in mice and
humans, resulting in secondary ischemic complications and high mortality. We show that, in …

Detection by near-infrared spectroscopy of large lipid core plaques at culprit sites in patients with acute ST-segment elevation myocardial infarction

RD Madder, JA Goldstein, SP Madden, R Puri… - JACC: Cardiovascular …, 2013 - jacc.org
Objectives: This study sought to describe near-infrared spectroscopy (NIRS) findings of
culprit lesions in ST-segment elevation myocardial infarction (STEMI). Background: Although …

Imaging of coronary atherosclerosis: intravascular ultrasound

HM Garcia-Garcia, MA Costa… - European heart …, 2010 - academic.oup.com
Atherosclerosis is the main cause of coronary heart disease, which is today the leading
cause of death worldwide and will continue to be the first in the world in 2030. In the …

Localized elevation of shear stress is related to coronary plaque rupture: a 3-dimensional intravascular ultrasound study with in-vivo color mapping of shear stress …

Y Fukumoto, T Hiro, T Fujii, G Hashimoto… - Journal of the American …, 2008 - jacc.org
Objectives: The purpose of the present study was to assess the relationship between shear
stress distribution and coronary plaque rupture by means of a new color-mapping program …

Comparison of coronary plaque rupture between stable angina and acute myocardial infarction: a three-vessel intravascular ultrasound study in 235 patients

MK Hong, GS Mintz, CW Lee, YH Kim, SW Lee… - Circulation, 2004 - Am Heart Assoc
Background—We evaluated the incidence and predictors of single and multiple plaque
ruptures in acute myocardial infarction (AMI) and stable angina pectoris (SAP). Methods and …