FOXO1, TGF-β regulation and wound healing

A Hameedaldeen, J Liu, A Batres, GS Graves… - International journal of …, 2014 - mdpi.com
Re-epithelialization is a complex process that involves migration and proliferation of
keratinocytes, in addition to the production of cytokines and growth factors that affect other …

From bench to bedside: use of human adipose-derived stem cells

V Feisst, S Meidinger, MB Locke - Stem cells and cloning …, 2015 - Taylor & Francis
Since the discovery of adipose-derived stem cells (ASC) in human adipose tissue nearly 15
years ago, significant advances have been made in progressing this promising cell therapy …

Keratinocyte function in normal and diabetic wounds and modulation by FOXO1

Y Wang, DT Graves - Journal of Diabetes Research, 2020 - Wiley Online Library
Diabetes has a significant and negative impact on wound healing, which involves complex
interactions between multiple cell types. Keratinocytes play a crucial role in the healing …

PPARβ/δ: linking metabolism to regeneration

A Magadum, FB Engel - International Journal of Molecular Sciences, 2018 - mdpi.com
In contrast to the general belief that regeneration is a rare event, mainly occurring in simple
organisms, the ability of regeneration is widely distributed in the animal kingdom. Yet, the …

The regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling

J Wang, B Cui, Z Chen, X Ding - Frontiers in cell and developmental …, 2022 - frontiersin.org
The epidermis, the outmost layer of the skin, is a stratified squamous epithelium that protects
the body from the external world. The epidermis and its appendages need constantly renew …

Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing

P Kakanj, B Moussian, S Grönke, V Bustos… - Nature …, 2016 - nature.com
Abstract The TOR and Insulin/IGF signalling (IIS) network controls growth, metabolism and
ageing. Although reducing TOR or insulin signalling can be beneficial for ageing, it can be …

Identification of Specific miRNAs in Neutrophils of Type 2 Diabetic Mice: Overexpression of miRNA-129-2-3p Accelerates Diabetic Wound Healing

T Umehara, R Mori, KA Mace, T Murase, Y Abe… - Diabetes, 2019 - Am Diabetes Assoc
Neutrophils are involved in the first stage of acute inflammation. After injury, they are
mobilized and recruited to the injured tissue. In diabetes, wound healing is delayed and …

Targeting miR‐223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds

M de Kerckhove, K Tanaka, T Umehara… - EMBO molecular …, 2018 - embopress.org
Argonaute 2 bound mature micro RNA (Ago2‐mi RNA) complexes are key regulators of the
wound inflammatory response and function in the translational processing of target mRNA s …

Constitutive immune activity promotes JNK-and FoxO-dependent remodeling of Drosophila airways

C Wagner, K Uliczka, J Bossen, X Niu, C Fink… - Cell Reports, 2021 - cell.com
Extensive remodeling of the airways is a major characteristic of chronic inflammatory lung
diseases such as asthma or chronic obstructive pulmonary disease (COPD). To elucidate …

Estimates of linkage disequilibrium and effective population sizes in Chinese Merino (Xinjiang type) sheep by genome-wide SNPs

S Liu, S He, L Chen, W Li, J Di, M Liu - Genes & Genomics, 2017 - Springer
Abstract Knowledge of linkage disequilibrium (LD) is important for effective genome-wide
association studies and accurate genomic prediction. Chinese Merino (Xinjiang type) is well …