Visceral adipose tissue (VAT) is a metabolic organ known to regulate fat mass, and glucose
and nutrient homeostasis. VAT is an active endocrine gland that synthesizes and secretes …

Adipose depots are heterogeneous tissues that store and sense fuel levels. Through the
secretion of lipids, cytokines, and protein hormones (adipokines), they communicate with …

As a cellular energy sensor and regulator, adenosine monophosphate (AMP)-activated
protein kinase (AMPK) plays a pivotal role in the regulation of energy homeostasis in both …

The adipokine adiponectin improves insulin sensitivity. Functional signal transduction of
adiponectin requires at least one of the receptors AdipoR1 or AdipoR2, but additionally the …

Dysfunctional visceral fat plays a key role in the initiation and maintenance of chronic
inflammation, liver steatosis and subsequent systemic insulin resistance that primes the …

Implant dentures become the first choice for denture restoration in patients with tooth loss.
However, oral implants often fail in osteoporosis (OP) patients. Melatonin (MT) induces …

Adiponectin is the adipokine associated with insulin sensitization, reducing liver
gluconeogenesis, and increasing fatty acid oxidation and glucose uptake. Adiponectin is …

In the liver, adiponectin regulates both glucose and lipid metabolism and exerts an insulin-
sensitizing effect. The binding of adiponectin with its specific receptors induces the activation …

Restricted-calorie diets are the most worldwide used treatments for obesity. Although such
strategies are based on the first law of thermodynamics, the real life clinical practice …

Rheumatoid arthritis (RA) is a systemic chronic inflammatory autoimmune joint disease,
characterized by progressive articular damage and joint dysfunction. One of the symptoms of …