Post-translational modifications (PTMs) endow proteins with new properties to respond to
environmental changes or growth needs. With the development of advanced proteomics …

The onset of amyotrophic lateral sclerosis is usually characterized by focal death of both
upper and/or lower motor neurons occurring in the motor cortex, basal ganglia, brainstem …

Deposits of the microtubule-associated protein Tau (MAPT) serve as a hallmark of
neurodegenerative diseases known as tauopathies. Numerous studies have demonstrated …

In this study, we observed worsening metabolic crosstalk in mouse models with concomitant
metabolic disorders such as hyperhomocysteinemia (HHcy), hyperlipidemia, and …

Background Alzheimer's disease (AD) is a progressive neurodegenerative disease that can
cause dementia. We aim to screen out the hub genes involved in AD based on microarray …

Background: Alzheimer's disease (AD) is associated with impaired cerebral circulation
which underscores diminished delivery of blood oxygen and nutrients to and throughout the …

Over 400 different types of post‐translational modifications (PTMs) have been reported and
over 200 various types of PTMs have been discovered using mass spectrometry (MS) …

Tau protein is a microtubule-associated protein that is widely distributed in the central
nervous system and maintains and regulates neuronal morphology and function. Tau …

Post-translational modifications (PTMs) regulate protein homeostasis and function. How
aging affects the landscape of PTMs remains largely elusive. Here, we reveal changes in …

Inflammation has a key role in driving memory/cognitive impairment in conditions ranging
from Alzheimer's disease, vascular dementia, Parkinson's disease, traumatic brain injury …