During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …

In healthy individuals, metabolically quiescent T cells survey lymph nodes and peripheral
tissues in search of cognate antigens. During infection, T cells that encounter cognate …

Melanoma is one of the most immunogenic tumors and its relationship with host immune
system is currently under investigation. Many immunomodulatory mechanisms, favoring …

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for 57% of
cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause a …

Although robust and highly effective anti-viral T cells contribute to the clearance of many
acute infections, viral persistence is associated with the development of functionally inferior …

Background FOLFOX is a combinational regimen of folinic acid (FnA, FOL), fluorouracil (5-
Fu, F) and oxaliplatin (OxP, OX), and has been long considered as the standard treatment of …

T lymphocytes, from their first encounter with their specific antigen as naïve cell until the last
stages of their differentiation, in a replicative state of senescence, go through a series of …

Tissue-resident memory T cells (TRM) persist at sites of prior infection and have been shown
to enhance pathogen clearance by recruiting circulating immune cells and providing …

Mucosal infections pose a significant global health burden. Antigen-specific tissue-resident
T cells are critical to maintaining barrier immunity. Previous studies in the context of systemic …

The adaptive immune system protects its host from a myriad of pathogens. This ability stems
from a vast set of lymphocytes, each with a different antigen receptor, a small number of …