Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades
because of advances in hematopoietic stem cell transplantation, immunosuppressive …

Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into
bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs …

Osteoclasts (OCLs) are key players in controlling bone remodeling. Modifications in their
differentiation or bone resorbing activity are associated with a number of pathologies …

The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being
of the host. Recent studies have demonstrated that the GM may significantly influence bone …

Tissue function depends on cellular organization. While the properties of individual cells are
increasingly being deciphered using powerful single-cell sequencing technologies …

No metazoan cell survives on its own, absent the signals and support of its milieu. For
multicellular life with specialized tissues to persist, organization is everything and so …

The actions of the immune system are finely tuned, involving complex communication and
coordination between diverse immune and non-immune cells across the tissues of the body …

Stem cells have the ability to self-renew and differentiate along multiple lineages, driving
tissue homeostasis and regeneration. Paradigms of unidirectional, hierarchical …

Continuous analysis of single cells, over several cell divisions and for up to weeks at a time,
is crucial to deciphering rare, dynamic and heterogeneous cell responses, which would …

Significance: Exposure to ionizing radiation (IR) as the result of nuclear accidents or terrorist
attacks is a significant threat and a major medical concern. Hematopoietic stem cell (HSC) …