Parathyroid hormone (PTH) is a critical regulator of skeletal development that promotes both
bone formation and bone resorption. Using microbiota depletion by wide-spectrum …

A central feature of atherosclerosis, the most prevalent chronic vascular disease and root
cause of myocardial infarction and stroke, is leukocyte accumulation in the arterial wall …

Haematopoiesis is governed by haematopoietic stem cells (HSCs) that produce all lineages
of blood and immune cells. The maintenance of blood homeostasis requires a dynamic …

Hematopoietic stem cells (HSCs) are rare, multipotent cells that generate via progenitor and
precursor cells of all blood lineages. Similar to normal hematopoiesis, leukemia is also …

The bone marrow (BM) microenvironment, also called the BM niche, is essential for the
maintenance of fully functional blood cell formation (hematopoiesis) throughout life. Under …

While regulatory T (Treg) cells are traditionally viewed as professional suppressors of
antigen presenting cells and effector T cells in both autoimmunity and cancer, recent …

Tissue homeostasis requires the presence of multipotent adult stem cells that are capable of
efficient self-renewal and differentiation; some of these have been shown to exist in a …

Significance: Reactive oxygen species (ROS), byproducts of aerobic metabolism, are
increased in many types of cancer cells. Increased endogenous ROS lead to adaptive …

Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal
and haematopoietic cells regulate their function. The steady state HSC niche has been …

Regulatory T (Treg) cells expressing the X-chromosome-encoded transcription factor Foxp3
represent a specialized immunosuppressive lineage with a well-recognized, essential …