Immune and inflammatory mechanisms of abdominal aortic aneurysm

AC Marquez-Sanchez, EK Koltsova - Frontiers in immunology, 2022 - frontiersin.org
Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-
mediated infiltration and a destruction of the aortic wall during AAA development plays …

Inflammatory cells in atherosclerosis

M Mehu, CA Narasimhulu, DK Singla - Antioxidants, 2022 - mdpi.com
Atherosclerosis is a chronic progressive disease that involves damage to the intima,
inflammatory cell recruitment and the accumulation of lipids followed by calcification and …

The innate immune system in cardiovascular diseases and its role in doxorubicin-induced cardiotoxicity

A Bhagat, P Shrestha, ES Kleinerman - International journal of molecular …, 2022 - mdpi.com
Innate immune cells are the early responders to infection and tissue damage. They play a
critical role in the initiation and resolution of inflammation in response to insult as well as …

Macrophage-based therapeutic approaches for cardiovascular diseases

M Sansonetti, B Al Soodi, T Thum, M Jung - Basic Research in Cardiology, 2024 - Springer
Despite the advances in treatment options, cardiovascular disease (CVDs) remains the
leading cause of death over the world. Chronic inflammatory response and irreversible …

Fibroblasts orchestrate cellular crosstalk in the heart through the ECM

SLK Bowers, Q Meng, JD Molkentin - Nature cardiovascular research, 2022 - nature.com
Cell communication is needed for organ function and stress responses, especially in the
heart. Cardiac fibroblasts, cardiomyocytes, immune cells and endothelial cells comprise the …

Multicellular regulation of miR-196a-5p and miR-425-5 from adipose stem cell-derived exosomes and cardiac repair

NC de Almeida Oliveira, EA Neri, CM Silva… - Clinical …, 2022 - portlandpress.com
Cardiac transplantation of adipose-derived stem cells (ASC) modulates the post-myocardial
infarction (post-MI) repair response. Biomolecules secreted or shuttled within extracellular …

Serotonin Receptors in Myocardial Infarction: Friend or Foe?

FS Bahr, M Ricke-Hoch, E Ponimaskin… - ACS Chemical …, 2024 - ACS Publications
Acute myocardial infarction (AMI) is one of the leading causes of death worldwide and
treatment costs pose a major burden on the global health care system. Despite the variety of …

Morphological Changes in the Myocardium of Patients with Post-Acute Coronavirus Syndrome: A Study of Endomyocardial Biopsies

I Makarov, S Mayrina, T Makarova, T Karonova… - Diagnostics, 2023 - mdpi.com
The clinical manifestation study of post-acute sequelae of SARS-CoV-2 infection (PASC)
has shown a lack of knowledge regarding its morphology and pathogenesis. The aim of this …

Doxorubicin-induced cardiotoxicity is mediated by neutrophils through release of neutrophil elastase

A Bhagat, P Shrestha, P Jeyabal, Z Peng… - Frontiers in …, 2022 - frontiersin.org
The mechanisms by which Doxorubicin (Dox) causes acute and late cardiotoxicity are not
completely understood. One understudied area is the innate immune response, and in …

Sex-and age-related differences in the inflammatory properties of cardiac fibroblasts: impact on the cardiosplenic axis and cardiac fibrosis

K Pappritz, SL Puhl, I Matz, E Brauer… - Frontiers in …, 2023 - frontiersin.org
Background Age and sex are prominent risk factors for heart failure and determinants of
structural and functional changes of the heart. Cardiac fibroblasts (cFB) are beyond their …