Critical role of hypoxia sensor-HIF-1α in VEGF gene activation. Implications for angiogenesis and tissue injury healing

A Ahluwalia, AS Tarnawski - Current medicinal chemistry, 2012 - ingentaconnect.com
Vascular injury of esophageal and gastrointestinal mucosa caused by injurious and
ulcerogenic factors leads to the cessation of blood flow, ischemia, and hypoxia and tissue …

Importin α: functions as a nuclear transport factor and beyond

M Oka, Y Yoneda - Proceedings of the Japan Academy, Series B, 2018 - jstage.jst.go.jp
Nucleocytoplasmic transport is an essential process in eukaryotes. The molecular
mechanisms underlying nuclear transport that involve the nuclear transport receptor, small …

[HTML][HTML] COMPARTMENTS: unification and visualization of protein subcellular localization evidence

JX Binder, S Pletscher-Frankild, K Tsafou, C Stolte… - Database, 2014 - academic.oup.com
Information on protein subcellular localization is important to understand the cellular
functions of proteins. Currently, such information is manually curated from the literature …

Tracking STAT nuclear traffic

NC Reich, L Liu - Nature Reviews Immunology, 2006 - nature.com
Accurate cellular localization is crucial for the effective function of most signalling molecules
and nuclear translocation is central to the function of transcription factors. The passage of …

The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation

D Kawamori, H Kaneto, Y Nakatani, T Matsuoka… - Journal of Biological …, 2006 - ASBMB
It has been shown that oxidative stress and activation of the c-Jun N-terminal kinase (JNK)
pathway induce the nucleocytoplasmic translocation of the pancreatic transcription factor …

Dual functional roles of dentin matrix protein 1: implications in biomineralization and gene transcription by activation of intracellular Ca2+ store

K Narayanan, A Ramachandran, J Hao, G He… - Journal of Biological …, 2003 - ASBMB
Dentin matrix protein 1 (DMP1) is a bone-and teeth-specific protein initially identified from
mineralized dentin. Here we report that DMP1 is primarily localized in the nuclear …

Oxidative Stress Induces Nucleo-Cytoplasmic Translocation of Pancreatic Transcription Factor PDX-1 Through Activation of c-Jun NH2-terminal Kinase

D Kawamori, Y Kajimoto, H Kaneto, Y Umayahara… - Diabetes, 2003 - Am Diabetes Assoc
Oxidative stress is induced in pancreatic β-cells under diabetic conditions and causes β-cell
dysfunction. Antioxidant treatment of diabetic animals leads to recovery of insulin …

Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination

L Lackey, EK Law, WL Brown, RS Harris - Cell Cycle, 2013 - Taylor & Francis
Humans have seven APOBEC3 DNA cytosine deaminases. The activity of these enzymes
allows them to restrict a variety of retroviruses and retrotransposons, but may also cause pro …

Nuclear localization of the Nipah virus W protein allows for inhibition of both virus-and toll-like receptor 3-triggered signaling pathways

ML Shaw, WB Cardenas, D Zamarin, P Palese… - Journal of …, 2005 - Am Soc Microbiol
The Nipah virus V and W proteins, which are encoded by the P gene via RNA editing, have
a common N-terminal domain but unique C-terminal domains. They localize to the …

Triggering neural differentiation of ES cells by subtype switching of importin-α

N Yasuhara, N Shibazaki, S Tanaka, M Nagai… - Nature cell …, 2007 - nature.com
Nuclear proteins are selectively imported into the nucleus by transport factors such as
importin-α and importin-β,. Here, we show that the expression of importin-α subtypes is …