Transcription factors (TFs) are indispensable for the modulation of various signaling
pathways associated with normal cell homeostasis and disease conditions. Among cancer …

Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer, accounting for
approximately 15% among all lung cancers. Despite the ability of chemotherapy, the first …

Background Ovarian cancer (OC) is one of the most common and most malignant
gynecological malignancies in gynecology. On the other hand, dysregulation of copper …

Probiotic roles of Clostridium butyricum (CB) are involved in regulating disease and cancers,
yet the mechanistic basis for these regulatory roles remains largely unknown. Here, we …

Evidence has revealed that transcription factors play essential roles in regulation of multiple
cellular processes, including cell proliferation, metastasis, EMT, cancer stem cells and …

Posttranslational modifications (PTMs), such as phosphorylation, methylation, ubiquitination,
and acetylation, are important in governing protein expression levels. Proteolysis targeting …

Cancer 'stemness' is fundamental to cancer existence. It defines the ability of cancer cells to
indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a …

Glioma is the most pervasive intracranial tumor in the central nervous system (CNS), with
glioblastoma (GBM) being the most malignant type having a highly heterogeneous cancer …

Cancer stem cells (CSCs) are considered to be responsible for tumor recurrence and
metastasis. Therefore, clarification of the mechanisms involved in CSC stemness …

Despite recent advances in molecularly targeted therapies and immunotherapies, the
effective treatment of advanced-stage cancers remains a largely unmet clinical need …