Background Increasing evidence shows that protection induced by acellular pertussis
vaccines is short-lived, requiring repeated booster vaccination to control pertussis disease …

Pertussis is a common respiratory infection caused by the bacterium Bordetella pertussis.
Although most cases occur in developing countries, it is considered endemic globally. The …

Pertussis is a highly contagious, vaccine-preventable respiratory tract infection, with high
morbidity and mortality and a particularly severe effect on newborns and infants under 2 …

Pertussis (whooping cough) is a severe infectious disease in infants less than 6 months old.
Mass vaccination programmes have been unable to halt transmission effectively. Strategies …

Background Despite widespread immunization programs, a clear increase in pertussis
incidence is apparent in many developed countries during the last decades. Consequently …

Background Vaccine against pertussis has been in use for several decades. Despite the
widespread use of pertussis vaccine, evidence shows resurgence of pertussis in high …

In Austria, vaccination coverage against Bordetella pertussis infections during infancy is
estimated at around 90%. Within the last years, however, the number of pertussis cases has …

Compared to whole cell pertussis (wcP) vaccines, acellular pertussis vaccines (aP) have a
better safety profile with lower reactogenicity, although their short and long-term efficacy was …

ABSTRACT Background: An acellular Pertussis (aP) vaccine containing recombinant
genetically detoxified Pertussis Toxin (PTgen), Filamentous Hemagglutinin (FHA) and …

BACKGROUND: China is the most populous country in the world, with an annual birth cohort
of approximately 16 million, requiring an average of 500 million vaccine doses administered …