[HTML][HTML] Standard of care versus new-wave corticosteroids in the treatment of Duchenne muscular dystrophy: Can we do better?
S Kourakis, CA Timpani, DG Campelj, P Hafner… - Orphanet Journal of …, 2021 - Springer
Background Pharmacological corticosteroid therapy is the standard of care in Duchenne
Muscular Dystrophy (DMD) that aims to control symptoms and slow disease progression …
Muscular Dystrophy (DMD) that aims to control symptoms and slow disease progression …
[HTML][HTML] Nuclear factor erythroid-2-related factor 2 signaling in the neuropathophysiology of inherited metabolic disorders
B Seminotti, M Grings, P Tucci, G Leipnitz… - Frontiers in Cellular …, 2021 - frontiersin.org
Inherited metabolic disorders (IMDs) are rare genetic conditions that affect multiple organs,
predominantly the central nervous system. Since treatment for a large number of IMDs is …
predominantly the central nervous system. Since treatment for a large number of IMDs is …
Ferulic acid and hormesis: Biomedical and environmental implications
The present paper provides the first systematic assessment of the capacity of ferulic acid to
induce hormetic dose responses in biological systems. Ferulic acid induced hormetic effects …
induce hormetic dose responses in biological systems. Ferulic acid induced hormetic effects …
[HTML][HTML] Calming the (Cytokine) storm: dimethyl fumarate as a therapeutic candidate for COVID-19
CA Timpani, E Rybalka - Pharmaceuticals, 2020 - mdpi.com
COVID-19 has rapidly spread worldwide and incidences of hospitalisation from respiratory
distress are significant. While a vaccine is in the pipeline, there is urgency for therapeutic …
distress are significant. While a vaccine is in the pipeline, there is urgency for therapeutic …
Saccharomyces boulardii Ameliorates Dextran Sulfate Sodium‐Induced Ulcerative Colitis in Mice by Regulating NF‐κB and Nrf2 Signaling Pathways
H Gao, Y Li, J Sun, H Xu, M Wang, X Zuo… - Oxidative Medicine …, 2021 - Wiley Online Library
Saccharomyces boulardii (S. boulardii) is a probiotic yeast that is widely used to treat
gastrointestinal disorders. The present study is aimed to explore the therapeutic effects of S …
gastrointestinal disorders. The present study is aimed to explore the therapeutic effects of S …
[HTML][HTML] Dimethyl fumarate modulates the dystrophic disease program following short-term treatment
New medicines are urgently required to treat the fatal neuromuscular disease Duchenne
muscular dystrophy (DMD). Dimethyl fumarate (DMF) is a potent immunomodulatory small …
muscular dystrophy (DMD). Dimethyl fumarate (DMF) is a potent immunomodulatory small …
Homeostasis and evolution in relation to regeneration and repair
A Cano‐Martínez, ME Rubio‐Ruiz… - The Journal of …, 2024 - Wiley Online Library
Homeostasis constitutes a key concept in physiology and refers to self‐regulating processes
that maintain internal stability when adjusting to changing external conditions. It diminishes …
that maintain internal stability when adjusting to changing external conditions. It diminishes …
[HTML][HTML] Redox homeostasis in muscular dystrophies
N Mosca, S Petrillo, S Bortolani, M Monforte, E Ricci… - Cells, 2021 - mdpi.com
In recent years, growing evidence has suggested a prominent role of oxidative stress in the
pathophysiology of several early-and adult-onset muscle disorders, although effective …
pathophysiology of several early-and adult-onset muscle disorders, although effective …
The hormetic response of heart rate of fish embryos to contaminants–implications for research and policy
E Agathokleous - Science of The Total Environment, 2022 - Elsevier
Evidence of contaminant-induced hormesis is rapidly accumulating, while the underlying
mechanisms of hormesis are becoming increasingly understood. Recent developments in …
mechanisms of hormesis are becoming increasingly understood. Recent developments in …
[HTML][HTML] Resveratrol alleviates zearalenone-induced intestinal dysfunction in mice through the NF-κB/Nrf2/HO-1 signalling pathway
S Xia, C Yan, J Gu, Y Yuan, H Zou, Z Liu, J Bian - Foods, 2024 - mdpi.com
Zearalenone (ZEA), a mycotoxin widely present in crops and food, poses a major threat to
animal and human health. The consumption of ZEA-contaminated food or feed causes …
animal and human health. The consumption of ZEA-contaminated food or feed causes …