[HTML][HTML] Standard of care versus new-wave corticosteroids in the treatment of Duchenne muscular dystrophy: Can we do better?

S Kourakis, CA Timpani, DG Campelj, P Hafner… - Orphanet Journal of …, 2021 - Springer
Background Pharmacological corticosteroid therapy is the standard of care in Duchenne
Muscular Dystrophy (DMD) that aims to control symptoms and slow disease progression …

[HTML][HTML] Nuclear factor erythroid-2-related factor 2 signaling in the neuropathophysiology of inherited metabolic disorders

B Seminotti, M Grings, P Tucci, G Leipnitz… - Frontiers in Cellular …, 2021 - frontiersin.org
Inherited metabolic disorders (IMDs) are rare genetic conditions that affect multiple organs,
predominantly the central nervous system. Since treatment for a large number of IMDs is …

Ferulic acid and hormesis: Biomedical and environmental implications

EJ Calabrese, E Agathokleous, V Calabrese - Mechanisms of ageing and …, 2021 - Elsevier
The present paper provides the first systematic assessment of the capacity of ferulic acid to
induce hormetic dose responses in biological systems. Ferulic acid induced hormetic effects …

[HTML][HTML] Calming the (Cytokine) storm: dimethyl fumarate as a therapeutic candidate for COVID-19

CA Timpani, E Rybalka - Pharmaceuticals, 2020 - mdpi.com
COVID-19 has rapidly spread worldwide and incidences of hospitalisation from respiratory
distress are significant. While a vaccine is in the pipeline, there is urgency for therapeutic …

Saccharomyces boulardii Ameliorates Dextran Sulfate Sodium‐Induced Ulcerative Colitis in Mice by Regulating NF‐κB and Nrf2 Signaling Pathways

H Gao, Y Li, J Sun, H Xu, M Wang, X Zuo… - Oxidative Medicine …, 2021 - Wiley Online Library
Saccharomyces boulardii (S. boulardii) is a probiotic yeast that is widely used to treat
gastrointestinal disorders. The present study is aimed to explore the therapeutic effects of S …

[HTML][HTML] Dimethyl fumarate modulates the dystrophic disease program following short-term treatment

CA Timpani, S Kourakis, DA Debruin, DG Campelj… - JCI insight, 2023 - ncbi.nlm.nih.gov
New medicines are urgently required to treat the fatal neuromuscular disease Duchenne
muscular dystrophy (DMD). Dimethyl fumarate (DMF) is a potent immunomodulatory small …

Homeostasis and evolution in relation to regeneration and repair

A Cano‐Martínez, ME Rubio‐Ruiz… - The Journal of …, 2024 - Wiley Online Library
Homeostasis constitutes a key concept in physiology and refers to self‐regulating processes
that maintain internal stability when adjusting to changing external conditions. It diminishes …

[HTML][HTML] Redox homeostasis in muscular dystrophies

N Mosca, S Petrillo, S Bortolani, M Monforte, E Ricci… - Cells, 2021 - mdpi.com
In recent years, growing evidence has suggested a prominent role of oxidative stress in the
pathophysiology of several early-and adult-onset muscle disorders, although effective …

The hormetic response of heart rate of fish embryos to contaminants–implications for research and policy

E Agathokleous - Science of The Total Environment, 2022 - Elsevier
Evidence of contaminant-induced hormesis is rapidly accumulating, while the underlying
mechanisms of hormesis are becoming increasingly understood. Recent developments in …

[HTML][HTML] Resveratrol alleviates zearalenone-induced intestinal dysfunction in mice through the NF-κB/Nrf2/HO-1 signalling pathway

S Xia, C Yan, J Gu, Y Yuan, H Zou, Z Liu, J Bian - Foods, 2024 - mdpi.com
Zearalenone (ZEA), a mycotoxin widely present in crops and food, poses a major threat to
animal and human health. The consumption of ZEA-contaminated food or feed causes …