Diabetes is associated with an increased risk of heart failure (HF). This is commonly termed
diabetic cardiomyopathy and is often characterised by increased cardiac fibrosis …

The prevalence of cardiovascular disease (CVD) has been rising due to sedentary lifestyles
and unhealthy dietary patterns. Peroxisome proliferator‐activated receptor α (PPARα) is a …

The E3 ubiquitin ligase HMG-CoA reductase degradation protein 1 (Hrd1) is a key enzyme
for ER-associated degradation of misfolded proteins. Its role in ischemic heart disease has …

Three members of the peroxisome proliferator-activated receptor (PPAR) family, PPARα,
PPARγ, and PPARβ/δ, have been investigated widely over the past few decades. Although …

Background The combined use of Aconiti Lateralis Radix Praeparata (ALRP) and Zingiberis
Rhizoma (ZR) are classic compatibilities in China for the treatment of cardiovascular …

Peroxisome proliferator-activated receptor-α (PPAR-α) belonging to the nuclear hormone
receptor superfamily is a promising target for CVDs which mechanistically improves the …

Higenamine (HG) is a well-known selective activator of beta2-adrenergic receptor (β2-AR)
with a positive inotropic effect. The present study showed that HG combined with [6]-gingerol …

The activation of peroxisome proliferator-activated receptor α (PPARα) is a key
pharmacological drug target for dyslipidemic management. Dyslipidemia is associated with …

Background and Objective: Retinal ischemia-reperfusion (IR) leads to massive loss of retinal
ganglion cells (RGC) and characterizes several blind-causing ophthalmic diseases …

Radiation-induced cardiovascular disease is associated with metabolic remodeling in the
heart, mainly due to the inactivation of the transcription factor peroxisome proliferator …