Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents
and the third most frequent in adults. Many inherited germline mutations are responsible for …

Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …

Importance Osteosarcoma, the most common malignant bone tumor in children and
adolescents, occurs in a high number of cancer predisposition syndromes that are defined …

Osteosarcoma derives from primitive bone-forming mesenchymal cells and is the most
common primary bone malignancy. The incidence rates and 95% confidence intervals of …

Osteosarcoma is a primary bone malignancy that typically occurs during adolescence but
also has a second incidence peak in the elderly. It occurs most commonly in the long bones …

Background Werner syndrome (WS) is an autosomal recessive genetic instability and
progeroid ('premature aging') syndrome which is associated with an elevated risk of cancer …

Osteosarcoma is a devastating but rare disease, whose study has illuminated both the basic
biology and clinical management of cancer over the past 30 years. These contributions have …

Studies to determine the etiology of osteosarcoma involve epidemiologic and environmental
factors and genetic impairments. Factors related to patient characteristics include age …

Osteosarcoma (OS) is the most common primary bone tumor affecting predominantly
adolescents and young adults. It accounts for about 5% of all childhood cancers. Although …

Progresses over the past years have extensively improved our capacity to use genome-
scale analyses—including high-density genotyping and exome and genome sequencing …