In the past two decades, several molecular targeted inhibitors have been developed and
evaluated clinically to improve the survival of patients with cancer. Molecular targeted …

Diabetic macular edema (DME) is a critical complication of diabetic retinopathy, a condition
that arises from the breakdown of the blood–retinal barrier and the consequent increase in …

For many decades classical anti-tumor therapies included chemotherapy, radiation and
surgery; however, in the last two decades, following the identification of the genomic drivers …

Asthma is a chronic and heterogenic disease of the respiratory system, one of the most
common lung diseases worldwide. The underlying pathologies, which are chronic …

Background Glioblastoma multiforme (GBM), a lethal brain tumor, remains the most daunting
challenge in cancer therapy. Overexpression and constitutive activation of PDGFs and …

Abstract PD-1/PD-L1 blockade has so far shown limited survival benefit for high-grade
ovarian carcinomas. By using paired samples from the NeoPembrOv randomized phase II …

Angiogenesis research in the past two decades has contributed significantly towards
understanding the molecular pathophysiology of cancer progression and inspired target …

Human cytomegalovirus (HCMV) infects the majority of the human population and
represents the leading viral cause of congenital birth defects. HCMV utilizes the …

Introduction The limited response to immune checkpoint blockades (ICBs) in patients with
hepatocellular carcinoma (HCC) highlights the urgent need for broadening the scope of …

Background Little is known about endogenous inhibitors of angiogenic growth factors. In this
study, we identified a novel endogenous anti-angiogenic factor expressed in pericytes and …