Cryptoglandular perianal fistula is a common benign anorectal disorder that is managed
mainly with surgery. A fistula is typically defined as a pathological communication between …

Perianal fistulizing Crohn's disease (CD) represents a severe phenotype of CD that is
associated with significant morbidity and reduction in quality of life. Perianal fistulizing CD is …

Background Exosome administration is a novel medical approach that promises excellent
immunomodulatory properties without the conventional side effects of current antitumor …

Background The therapeutic role of methotrexate (MTX) for management of inflammatory
bowel disease (IBD) remains unclear. Methods We systematically reviewed randomized …

Abstract Purpose of Review Inflammatory bowel diseases (IBD), which include Crohn's
disease (CD) and ulcerative colitis (UC), are chronic, relapsing diseases with unknown …

Simple Summary Cancer arising at the site of a chronic perianal fistula is rare in patients
with Crohn's disease. The relationship between perianal fistula in CD (Chron's disease) and …

ABSTRACT Introduction Perianal fistulizing Crohn's disease is associated with a poor
quality of life and current medical and surgical treatment options are limited. Darvadstrocel …

Background Fistulas represent a frequent and severe complication in patients with Crohn
disease (CD). Tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta, and …

Regenerative medicine is an emerging therapeutic method that aims to reconstruct tissues
and organs. This advanced therapeutic approach has demonstrated great potential in …

Perianal fistulas, also known as anal furunculosis, are painful sinus tracts or ulcers that
spontaneously occur in the skin around the anus (Fig. 1). German shepherd dogs are …