Objective We tested the hypothesis that skeletal muscle of endurance-trained male runners
would exhibit elevated autophagy and mitophagy markers, which would be associated with …

The purpose of this review is to provide information about the role of exercise in the
prevention of skeletal muscle insulin resistance, that is, the inability of insulin to properly …

Endothelial dysfunction and insulin resistance are frequently comorbid states. Vasodilator
actions of insulin are mediated by phosphatidylinositol 3-kinase (PI3K)-dependent signaling …

The sirtuins are a family of nicotinamide adenine dinucleotide (NAD+)-dependent protein
deacetylases that regulate cell survival, metabolism, and longevity. Humans have seven …

Known genetic susceptibility loci for type 2 diabetes (T2D) explain only a small proportion of
heritable T2D risk. We hypothesize that DNA methylation patterns may contribute to variation …

Intra‐abdominal obesity is an important risk factor for low‐grade inflammation, which is
associated with increased risk for diabetes mellitus and cardiovascular disease. For the …

Type 2 diabetes mellitus (T2D) is characterized by insulin resistance, impaired glycogen
synthesis, lipid accumulation, and impaired mitochondrial function. Exercise training has …

Mounting evidence suggests a role for mitochondrial dysfunction in the pathogenesis of
many diseases, including type 2 diabetes, aging, and ovarian failure. Because of the central …

Limitations in physical fitness, a consistent finding in individuals with both type I and type 2
diabetes mellitus, correlate strongly with cardiovascular and all-cause mortality. These …

Magnetic resonance spectroscopy (MRS) can give information about cellular metabolism in
vivo which is difficult to obtain in other ways. In skeletal muscle, non‐invasive 31 P MRS …