A growing number of clinical and epidemiological studies support the hypothesis of a tight
correlation between type 2 diabetes mellitus (T2DM) and the development risk of …

An alarming increase in the prevalence of obesity, type 2 diabetes mellitus, and associated
diseases can be observed world-wide during the past 20 years. In obesity, profound …

Dysfunctional adipose tissue is associated with an increased risk of developing type 2
diabetes (T2D). One characteristic of a dysfunctional adipose tissue is the reduced …

Studies in genetic and dietary obese animal models, genetically modified animals and
humans with obesity or type 2 diabetes suggest plausible mechanisms for effects of fatty …

OBJECTIVE The contribution of mitochondrial dysfunction to skeletal muscle insulin
resistance remains elusive. Comparative proteomics are being applied to generate new …

Glucose, fatty acids, and amino acids among others are oxidized to generate adenosine
triphosphate (ATP). These fuels are supplied from the environment (through food intake) and …

Insulin has an exercise-like action to increase microvascular perfusion of skeletal muscle
and thereby enhance delivery of hormone and nutrient to the myocytes. With insulin …

Insulin resistance is a key defect associated with obesity and type-2 diabetes. The precise
factors that lead to insulin resistance have not been elucidated fully, but there is a strong …

Many human diseases are caused by an imbalance between energy production and
demand. Magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) …

In exercise science, the crossover effect denotes that fat oxidation is the primary fuel at rest
and during low-intensity exercise with a shift towards an increased reliance on carbohydrate …