The pathophysiology underlying mitochondrial dysfunction in insulin-resistant skeletal
muscle is incompletely characterized. To further delineate this we investigated the …

Endurance exercise training is accompanied by physiological changes that improve muscle
function and performance. Several studies have demonstrated that markers of mitochondrial …

Several studies indicated that ginger (Zingiber officinale Roscoe) enhances thermogenesis
and/or energy expenditure with which to interpret the beneficial effects of ginger on …

Alterations in muscle mitochondrial substrate preference have been postulated to play a
major role in the pathogenesis of muscle insulin resistance. In order to examine this …

Aims/hypothesis Intramyocellular lipids (IMCL) accumulation is a classical feature of
metabolic diseases. We hypothesised that IMCL accumulate mainly as a consequence of …

Despite the central role of the liver in the regulation of glucose and lipid metabolism, there
are currently no methods to directly assess hepatic oxidative metabolism in humans in vivo …

Maternal obesity is proposed to alter the programming of metabolic systems in the offspring,
increasing the risk for developing metabolic diseases; however, the cellular mechanisms …

The beneficial effects of exercise in patients with type 1 diabetes (T1D) are not fully proven,
given that it may occasionally induce acute metabolic disturbances. Indeed, the metabolic …

A single-nucleotide polymorphism in the human arylamine N-acetyltransferase 2 (Nat2)
gene has recently been identified as associated with insulin resistance in humans. To …

Resistance to thyroid hormone (RTH), a dominantly inherited disorder usually associated
with mutations in thyroid hormone receptor β (THRB), is characterized by elevated levels of …