PGC-1α integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle
I Pagel-Langenickel, J Bao, JJ Joseph… - Journal of Biological …, 2008 - ASBMB
The pathophysiology underlying mitochondrial dysfunction in insulin-resistant skeletal
muscle is incompletely characterized. To further delineate this we investigated the …
muscle is incompletely characterized. To further delineate this we investigated the …
Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals
DE Befroy, KF Petersen, S Dufour… - Proceedings of the …, 2008 - National Acad Sciences
Endurance exercise training is accompanied by physiological changes that improve muscle
function and performance. Several studies have demonstrated that markers of mitochondrial …
function and performance. Several studies have demonstrated that markers of mitochondrial …
Promotion of Mitochondrial Biogenesis via Activation of AMPK‐PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active …
X Deng, S Zhang, J Wu, X Sun, Z Shen… - Journal of food …, 2019 - Wiley Online Library
Several studies indicated that ginger (Zingiber officinale Roscoe) enhances thermogenesis
and/or energy expenditure with which to interpret the beneficial effects of ginger on …
and/or energy expenditure with which to interpret the beneficial effects of ginger on …
Dissociation of muscle insulin resistance from alterations in mitochondrial substrate preference
Alterations in muscle mitochondrial substrate preference have been postulated to play a
major role in the pathogenesis of muscle insulin resistance. In order to examine this …
major role in the pathogenesis of muscle insulin resistance. In order to examine this …
Intramyocellular lipid accumulation is associated with permanent relocation ex vivo and in vitro of fatty acid translocase (FAT)/CD36 in obese patients
C Aguer, J Mercier, C Yong Wai Man, L Metz… - Diabetologia, 2010 - Springer
Aims/hypothesis Intramyocellular lipids (IMCL) accumulation is a classical feature of
metabolic diseases. We hypothesised that IMCL accumulate mainly as a consequence of …
metabolic diseases. We hypothesised that IMCL accumulate mainly as a consequence of …
Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy
Despite the central role of the liver in the regulation of glucose and lipid metabolism, there
are currently no methods to directly assess hepatic oxidative metabolism in humans in vivo …
are currently no methods to directly assess hepatic oxidative metabolism in humans in vivo …
[HTML][HTML] Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques
Maternal obesity is proposed to alter the programming of metabolic systems in the offspring,
increasing the risk for developing metabolic diseases; however, the cellular mechanisms …
increasing the risk for developing metabolic diseases; however, the cellular mechanisms …
Metabolomics approach for analyzing the effects of exercise in subjects with type 1 diabetes mellitus
L Brugnara, M Vinaixa, S Murillo, S Samino… - PloS one, 2012 - journals.plos.org
The beneficial effects of exercise in patients with type 1 diabetes (T1D) are not fully proven,
given that it may occasionally induce acute metabolic disturbances. Indeed, the metabolic …
given that it may occasionally induce acute metabolic disturbances. Indeed, the metabolic …
Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice
JP Camporez, Y Wang, K Faarkrog… - Proceedings of the …, 2017 - National Acad Sciences
A single-nucleotide polymorphism in the human arylamine N-acetyltransferase 2 (Nat2)
gene has recently been identified as associated with insulin resistance in humans. To …
gene has recently been identified as associated with insulin resistance in humans. To …
Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia
CS Mitchell, DB Savage, S Dufour… - The Journal of …, 2010 - Am Soc Clin Investig
Resistance to thyroid hormone (RTH), a dominantly inherited disorder usually associated
with mutations in thyroid hormone receptor β (THRB), is characterized by elevated levels of …
with mutations in thyroid hormone receptor β (THRB), is characterized by elevated levels of …