Belumosudil, an investigational oral selective inhibitor of Rho-associated coiled-coil–
containing protein kinase 2 (ROCK2), reduces type 17 and follicular T helper cells via …

PURPOSE The rho-associated coiled-coil–containing protein kinase-2 (ROCK2) signaling
pathway regulates the Th17/regulatory T cells balance and controls profibrotic pathways …

Simple Summary Due to its graft-versus-myeloma effect, allogeneic hematopoietic stem cell
transplantation (allo-SCT) can enable long-term survival or even cure in carefully selected …

Novel drugs have improved survival for patients with multiple myeloma in recent years.
However, the disease is still fatal. Allogeneic stem cell transplantation (Allo) has proven to …

Recommendations are based on a review of the literature using Medline, PubMed, Embase,
Central, Web of Science searches from the beginning of 2013 up to July 2019. The following …

Allogeneic hematopoietic cell transplant (HCT) may improve long-term multiple myeloma
(MM) control through the graft-versus-myeloma effect. The Blood and Marrow Transplant …

Graft-versus-host disease (GVHD) remains among the major causes of treatment failure in
patients with multiple myeloma (MM) undergoing allogeneic hematopoietic cell …

Major progress in the treatment of multiple myeloma has been made in the last several
years. However, myeloma remains incurable and patients with high-risk cytogenetics or …

The third annual Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Myeloma
Intergroup Workshop on Minimal Residual Disease and Immune Profiling was held on …

Simple Summary Multiple myeloma is a hematological malignancy arising from the
proliferation of tumor antibody-producing cells in the bone marrow. In this cancer, tumor …