Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

The human immune system is highly variable between individuals but relatively stable over
time within a given person. Recent conceptual and technological advances have enabled …

The presence of DNA in the cytoplasm of mammalian cells is a danger signal that triggers
host immune responses such as the production of type I interferons. Cytosolic DNA induces …

Autoantibodies against nucleic acids and excessive type I interferon (IFN) are hallmarks of
human systemic lupus erythematosus (SLE). We previously reported that SLE neutrophils …

Signals controlling the generation of regulatory B (Breg) cells remain ill-defined. Here we
report an" auto"-regulatory feedback mechanism between plasmacytoid dendritic cells …

In the midst of resurging COVID-19 cases, the second NIH/FDA virtual COVID-19 and
Cytokines symposium was held on 1 December 2020, focusing on longitudinal studies of …

Detection of nucleic acids and induction of type I interferons (IFNs) are principal elements of
antiviral defense but can cause autoimmunity if misregulated. Cytosolic DNA detection …

Objectives To assess the efficacy of the interleukin 1 receptor antagonist anakinra in
systemic-onset juvenile idiopathic arthritis (SJIA). Methods A multicentre, randomised …

Objective MicroRNA have recently been identified as regulators that modulate target gene
expression and are involved in shaping the immune response. This study was undertaken to …

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of
diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous …