Sprouting angiogenesis is a dynamic process in which endothelial cells collectively migrate,
shape new lumenized tubes, make new connections, and remodel the nascent network into …

Members of the Notch family of transmembrane receptors play an important role in cell fate
determination. Over the past decade, a role for Notch in the pathogenesis of hematologic …

Tumour growth requires accompanying expansion of the host vasculature, with tumour
progression often correlated with vascular density. Vascular endothelial growth factor …

The Notch signaling pathway has been demonstrated to play a critical role during
mammalian cardiac development based on recent findings from gene-targeted mice. In …

It has become increasingly clear that the Notch signaling pathway plays a critical role in the
development and homeostasis of the cardiovascular system. This notion has emerged from …

The Notch ligand, Dll4, is essential for angiogenesis during embryonic vascular
development and is involved in tumour angiogenesis. Several recent publications …

Intercellular signaling mediated by Notch receptors is essential for proper cardiovascular
development and homeostasis. Notch regulates cell fate decisions that affect proliferation …

Tumor angiogenesis is a complex process and involves the tight interplay of tumor cells,
endothelial cells, phagocytes and their secreted factors, which may act as promoters or …

In adults, angiogenic abnormalities are involved in not only tumor growth but several human
inherited diseases as well. It is unclear, however, concerning how the normal vascular …

The critical contribution of the Notch signaling pathway to vascular morphogenesis has been
underscored by loss-of-function studies in mouse and zebrafish. Nonetheless, a …