Pulmonary innate immune response determines the outcome of inflammation during pneumonia and sepsis-associated acute lung injury

V Kumar - Frontiers in immunology, 2020 - frontiersin.org
The lung is a primary organ for gas exchange in mammals that represents the largest
epithelial surface in direct contact with the external environment. It also serves as a crucial …

NK cells: A double edge sword against SARS-CoV-2

E Masselli, M Vaccarezza, C Carubbi, G Pozzi… - Advances in biological …, 2020 - Elsevier
Natural killer (NK) cells are pivotal effectors of the innate immunity protecting an individual
from microbes. They are the first line of defense against invading viruses, given their …

[HTML][HTML] Distinct early serological signatures track with SARS-CoV-2 survival

C Atyeo, S Fischinger, T Zohar, MD Slein, J Burke… - Immunity, 2020 - cell.com
As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some
individuals recover from infection, whereas others rapidly progress and die. Although the …

Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates

T Zohar, JC Hsiao, N Mehta, J Das, A Devadhasan… - Cell host & …, 2022 - cell.com
Respiratory syncytial virus (RSV) infection is a major cause of respiratory illness in infants
and the elderly. Although several vaccines have been developed, none have succeeded in …

Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates

MD Fahlberg, RV Blair, LA Doyle-Meyers… - Nature …, 2020 - nature.com
Understanding SARS-CoV-2 associated immune pathology is crucial to develop pan-
effective vaccines and treatments. Here we investigate the immune events from the acute …

Toxicology of flavoring-and cannabis-containing e-liquids used in electronic delivery systems

AB Stefaniak, RF LeBouf, AC Ranpara… - Pharmacology & …, 2021 - Elsevier
Electronic cigarettes (e-cigarettes) were introduced in the United States in 2007 and by 2014
they were the most popular tobacco product amongst youth and had overtaken use of …

Tissue-resident NK cells: development, maturation, and clinical relevance

E Hashemi, S Malarkannan - Cancers, 2020 - mdpi.com
Natural killer (NK) cells belong to type 1 innate lymphoid cells (ILC1) and are essential in
killing infected or transformed cells. NK cells mediate their effector functions using non …

NK cell exhaustion in the tumor microenvironment

H Jia, H Yang, H Xiong, KQ Luo - Frontiers in Immunology, 2023 - frontiersin.org
Natural killer (NK) cells kill mutant cells through death receptors and cytotoxic granules,
playing an essential role in controlling cancer progression. However, in the tumor …

[HTML][HTML] The role of microbiota in respiratory health and diseases, particularly in tuberculosis

T Shah, Z Shah, Z Baloch, XM Cui - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Trillions of beneficial and hostile microorganisms live in the human respiratory and
gastrointestinal tracts, which act as gatekeepers in maintaining human health, ie, protecting …

NK cells in cancer: mechanisms of dysfunction and therapeutic potential

F Portale, D Di Mitri - International Journal of Molecular Sciences, 2023 - mdpi.com
Natural killer cells (NK) are innate lymphocytes endowed with the ability to recognize and kill
cancer cells. Consequently, adoptive transfer of autologous or allogeneic NK cells …