[HTML][HTML] Modulation of ER-mitochondria tethering complex VAPB-PTPIP51: Novel therapeutic targets for aging-associated diseases
T Jiang, N Ruan, P Luo, Q Wang, X Wei, Y Li… - Ageing Research …, 2024 - Elsevier
Aging is a gradual and irreversible natural process. With aging, the body experiences a
functional decline, and the effects amplify the vulnerability to a range of age-related …
functional decline, and the effects amplify the vulnerability to a range of age-related …
Aberrant evoked calcium signaling and nAChR cluster morphology in a SOD1 D90A hiPSC-derived neuromuscular model
N Couturier, SJ Hörner, E Nürnberg… - Frontiers in Cell and …, 2024 - frontiersin.org
Familial amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disorder that is
due to mutations in one of several target genes, including SOD1. So far, clinical records …
due to mutations in one of several target genes, including SOD1. So far, clinical records …
Oxysterols in central and peripheral synaptic communication
AM Petrov - Implication of Oxysterols and Phytosterols in Aging and …, 2023 - Springer
Cholesterol is a key molecule for synaptic transmission, and both central and peripheral
synapses are cholesterol rich. During intense neuronal activity, a substantial portion of …
synapses are cholesterol rich. During intense neuronal activity, a substantial portion of …
Mechanism of Purinergic Regulation of Neurotransmission in Mouse Neuromuscular Junction: The Role of Redox Signaling and Lipid Rafts
AR Giniatullin, KA Mukhutdinova, AM Petrov - Neurochemical Research, 2024 - Springer
Acetylcholine is the main neurotransmitter at the vertebrate neuromuscular junctions (NMJs).
ACh exocytosis is precisely modulated by co-transmitter ATP and its metabolites. It is …
ACh exocytosis is precisely modulated by co-transmitter ATP and its metabolites. It is …
[HTML][HTML] Functional and Structural Changes in Diaphragm Neuromuscular Junctions in Early Aging
AN Tsentsevitsky, GV Sibgatullina… - International Journal of …, 2024 - mdpi.com
Age-related impairment of the diaphragm causes respiratory complications. Neuromuscular
junction (NMJ) dysfunction can be one of the triggering events in diaphragm weaknesses in …
junction (NMJ) dysfunction can be one of the triggering events in diaphragm weaknesses in …
Effects of membrane cholesterol-targeting chemicals on skeletal muscle contractions evoked by direct and indirect stimulation
NS Fedorov, AI Malomouzh, AM Petrov - Journal of Muscle Research and …, 2024 - Springer
Cholesterol is one of the major components of plasma membrane, where its distribution is
nonhomogeneous and it participates in lipid raft formation. In skeletal muscle cholesterol …
nonhomogeneous and it participates in lipid raft formation. In skeletal muscle cholesterol …
Endocytosis of Synaptic Vesicle in Motor Nerve Endings of FUS Transgenic Mice with a Model of Amyotrophic Lateral Sclerosis
PN Grigoryev, GA Gaptrakhmanova… - Bulletin of Experimental …, 2024 - Springer
In experiments on the motor nerve endings of the diaphragm of transgenic FUS mice with a
model of amyotrophic lateral sclerosis at the pre-symptomatic stage of the disease, the …
model of amyotrophic lateral sclerosis at the pre-symptomatic stage of the disease, the …
[HTML][HTML] Understanding the influence of altered lipid metabolism on TDP-43 pathology: a protocol for a systematic review and meta-analysis
Background: TDP-43 aggregation is the hallmark pathology seen at post-mortem in the
majority of Amyotrophic lateral sclerosis (ALS) cases. Lipid metabolism has been shown to …
majority of Amyotrophic lateral sclerosis (ALS) cases. Lipid metabolism has been shown to …
Understanding the influence of altered lipid metabolism on TDP-43 pathology: a protocol for a systematic review and meta-analysis
Background: TDP-43 aggregation is the hallmark pathology seen at post-mortem in the
majority of Amyotrophic lateral sclerosis (ALS) cases. Lipid metabolism has been shown to …
majority of Amyotrophic lateral sclerosis (ALS) cases. Lipid metabolism has been shown to …
Clinical Effectiveness of Physical training incorporating Tuina therapy in Patients with Amyotrophic lateral sclerosis: study protocol for a randomized controlled trial
D Yang, Q Zhu, Y Zhao, G Chen - 2023 - researchsquare.com
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, as the
limitations of drug therapies, there is an increasing focus on a rehabilitation approach that …
limitations of drug therapies, there is an increasing focus on a rehabilitation approach that …