Developmental mechanisms underlying the evolution of human cortical circuits

P Vanderhaeghen, F Polleux - Nature Reviews Neuroscience, 2023 - nature.com
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

[HTML][HTML] What risk factors for Developmental Language Disorder can tell us about the neurobiological mechanisms of language development

T Boerma, S Ter Haar, R Ganga, F Wijnen… - Neuroscience & …, 2023 - Elsevier
Abstract Language is a complex multidimensional cognitive system that is connected to
many neurocognitive capacities. The development of language is therefore strongly …

Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis

JJ Tielbeek, E Uffelmann, BS Williams… - Molecular …, 2022 - nature.com
Despite the substantial heritability of antisocial behavior (ASB), specific genetic variants
robustly associated with the trait have not been identified. The present study by the Broad …

Shared genetic liability and causal effects between major depressive disorder and insomnia

A Baranova, H Cao, F Zhang - Human Molecular Genetics, 2022 - academic.oup.com
Deciphering the genetic relationships between major depressive disorder (MDD) and
insomnia may facilitate understanding biological mechanisms as well as inform more …

Sequence variants affecting voice pitch in humans

RS Gisladottir, A Helgason, BV Halldorsson… - Science …, 2023 - science.org
The genetic basis of the human vocal system is largely unknown, as are the sequence
variants that give rise to individual differences in voice and speech. Here, we couple data on …

Developmental disorders caused by haploinsufficiency of transcriptional regulators: a perspective based on cell fate determination

R Zug - Biology Open, 2022 - journals.biologists.com
Many human birth defects and neurodevelopmental disorders are caused by loss-of-function
mutations in a single copy of transcription factor (TF) and chromatin regulator genes …

Dissecting the neurobiology of linguistic disorganisation and impoverishment in schizophrenia

L Palaniyappan - Seminars in cell & developmental biology, 2022 - Elsevier
Schizophrenia provides a quintessential disease model of how disturbances in the
molecular mechanisms of neurodevelopment lead to disruptions in the emergence of …

An investigation of barriers and enablers for genetics in speech-language pathology explored through a case study of childhood apraxia of speech

ML Lauretta, A Jarmolowicz, DJ Amor, S Best… - Journal of Speech …, 2023 - ASHA
Purpose: Advancements in genetic testing and analysis have allowed improved
identification of the genetic basis of childhood apraxia of speech, a rare speech …

Dissecting the cross-trait effects of the FOXP2 GWAS hit on clinical and brain phenotypes in adults with ADHD

GP Meyer, BS da Silva, CE Bandeira… - European Archives of …, 2023 - Springer
Abstract The Forkhead box P2 (FOXP2) encodes for a transcription factor with a broad role
in embryonic development. It is especially represented among GWAS hits for …

Differences in cortical surface area in developmental language disorder

N Bahar, GJ Cler, S Krishnan, SS Asaridou… - Neurobiology of …, 2024 - direct.mit.edu
Approximately 7% of children have developmental language disorder (DLD), a
neurodevelopmental condition associated with persistent language learning difficulties …