Necroptosis is a form of programmed necrosis that is mediated by various cytokines and
pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes …

Abstract Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …

Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

Cancer therapy is aimed at the elimination of tumor cells and acts via the cessation of cell
proliferation and induction of cell death. Many research publications discussing the …

In the last 10 years, mortality from acute myocardial infarction (AMI) has not significantly
decreased. This situation is associated with the absence in clinical practice of highly …

Tumor necrosis factor α (TNF-α) is a pro-inflammatory cytokine capable of inducing extrinsic
apoptosis and necroptosis. Tumor necrosis factor receptor-associated factor 6 (TRAF6), an …

Abstract ABIN-1, also called TNIP1, is an ubiquitin-binding protein that serves an important
role in suppressing RIPK1-independent apoptosis, necroptosis, and NF-κB activation …

Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 are signaling adaptors that
critically regulate cell death and inflammation. Tumors have adapted to subvert RIPK …

Abstract c-Myc is a proto-oncoprotein that regulates various cellular processes and whose
abnormal expression leads to tumorigenesis. c-Myc protein stability has been shown to be …

Ferroptosis is a newly discovered cell death type which is different from apoptosis,
autophagy, pyroptosis as well as necrosis in the following aspects: morphology …