Fibroblasts in the tumor stroma are well recognized as having an indispensable role in
carcinogenesis, including in the initiation of epithelial tumor formation. The association …

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

Angiogenesis has become an attractive target for drug therapy because of its key role in
tumor growth. An extensive array of compounds is currently in preclinical development, with …

Integrin ανβ3 is found on a subset of tumor blood vessels where it is associated with
angiogenesis and malignant tumor growth. We designed an ανβ3-targeted nanoparticle …

Since in most tumors multiple signaling pathways are involved, many of the inhibitors in
clinical development are designed to affect a wide range of targeted kinases. The most …

Recent clinical trials have shown several multi-target tyrosine kinase inhibitors (TKIs) to be
effective in the treatment of osteosarcoma. However, these TKIs have a number of targets …

Selective tyrosine kinase inhibitors have emerged as important therapeutic agents in the
treatment of a variety of human malignancies. Although several of these inhibitors have …

Background Antiangiogenesis tyrosine kinase inhibitors (TKIs) have been shown to prolong
progression‐free survival (PFS) in advanced osteosarcoma. Methylsulfonic apatinib is a TKI …

AKT/PKB (Protein Kinase B) are central proteins mediating signals from receptor tyrosine
kinases and phosphatidylinositol 3-kinase. AKT kinases are involved in a number of …

Purpose Chemotherapy treatment in premenopausal women has been linked to ovarian
follicle loss and premature ovarian failure; the exact mechanism by which this occurs is …