Osteosarcomas (OS), especially those with metastatic or unresectable disease, have limited
treatment options. The greatest advancement in treatments occurred in the 1980s when …

A new liquid chromatography–tandem mass spectrometry (LC–MS/MS) method, performed
by electrospray ionization in positive mode using a triple quadrupole mass spectrometry …

Cancer is responsible for one in eight deaths worldwide, with more than twelve million new
cases diagnosed yearly. A large percentage of patients die after developing cancer despite …

The vascular endothelial growth factor (VEGF) family and its receptors play fundamental
roles not only in physiological but also in pathological angiogenesis, characteristic of cancer …

Introduction: Inhibition of protein kinases has become a standard of modern clinical
oncology. PIM1 belongs to a novel class of serine/threonine kinases with distinct molecular …

Realizing the promise of molecularly targeted inhibitors for cancer therapy will require a new
level of knowledge about how a drug target is wired into the control circuitry of a complex …

Immunotherapy for solid tumors has shown promise in preclinical as well as early clinical
studies. However, its efficacy remains limited. The hindrance to achieving objective, long …

The protein kinase family, one of the largest gene families in eukaryotes, plays an important
role in regulating various cellular processes such as cell proliferation, cell death, cell cycle …

Polymorphonuclear neutrophils (PMN) are the most abundant circulating immune cells and
represent the first line of immune defense against infection. This review of the biomedical …

Growth factors and their corresponding receptors are commonly overexpressed and/or
dysregulated in many cancers including hepatocellular cancer (HCC). Clinical trials indicate …