Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children,
adolescents, and young adults, and with a second peak of incidence in elderly individuals …

Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …

Osteosarcoma, the most common malignant tumor of the bone, seriously influences people's
lives and increases their economic burden. Conventional chemotherapy drugs achieve …

Background Tyrosine kinase inhibitors have shown activity in osteosarcoma and might
enhance the efficacy of chemotherapy. We aimed to determine the recommended phase 2 …

Bone microenvironment provides growth and survival signals essential for osteosarcoma
(OS) initiation and progression. OS cells regulate communications inside tumor …

Background Antiangiogenesis tyrosine kinase inhibitors (TKIs) have been shown to prolong
progression‐free survival (PFS) in advanced osteosarcoma. Methylsulfonic apatinib is a TKI …

Background Disappointing clinical efficacy of standard treatment has been proven in
refractory metastatic osteosarcoma, and the emerging anti-angiogenic regimens are still in …

Strategies targeted vascular endothelial growth factor (VEGF)-dependent osteosarcoma
progression are limited although important progress has been made in illustrating the …

Background We report results from the phase I dose-finding and phase II expansion part of a
multicenter, open-label study of single-agent lenvatinib in pediatric and young adult patients …

Cancer is a common malignant disease worldwide with an increasing mortality in recent
years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the …