The consumption of caffeine in response to insufficient sleep may impair the onset and
maintenance of subsequent sleep. This systematic review and meta-analysis investigated …

For hundreds of years, mankind has been influencing its sleep and waking state through the
adenosinergic system. For~ 100 years now, systematic research has been performed, first …

Following critical evaluation of the available literature to date, The International Society of
Sports Nutrition (ISSN) position regarding caffeine intake is as follows: Supplementation with …

The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …

Objective This review aims to determine whether, and to what extent, dietary caffeine may be
a risk to cardiovascular health. Methods A critical review of the relevant experimental and …

The locomotor stimulatory effects induced by caffeine (1, 3, 7-trimethylxanthine) in rodents
have been attributed to antagonism of adenosine A 1 and A 2A receptors. Little is known …

Caffeine is a commonly used neurostimulant that also produces cerebral vasoconstriction by
antagonizing adenosine receptors. Chronic caffeine use results in an adaptation of the …

CD73 is a cell surface enzyme of the purine catabolic pathway that catalyzes the breakdown
of AMP to adenosine. Because of the strong immunosuppressive and antiinflammatory …

In vivo developmental neurotoxicity (DNT) testing is resource intensive and lacks information
on cellular processes affected by chemicals. To address this, DNT new approach …